Laura I Yousif, Aukje G Sijtema, Margot J Chevalier, Rudolf A de Boer, Wouter C Meijers
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引用次数: 0
Abstract
Purpose of review: We summarise the current knowledge of T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) across innate and adaptive immune cells and compile emerging evidence in cardiovascular disease (CVD).
Recent findings: Immune checkpoints have come to light as potent regulators of immune responses in tumour biology, autoimmune disease and, more recently, in CVD. TIM-3 is a complex immune checkpoint expressed on both immune and non-immune cells. It has four known ligands, two of which are only available for binding upon cell damage or death, and binding can be either stimulatory or inhibitory. It functions as a context-dependent modulator of immune reactions in atherosclerosis, myocardial infarction and myocarditis. TIM-3 may exert functions in the cardiovascular system, but more mechanistic research is required to investigate whether interference with TIM-3 signalling can be used to improve cardiovascular health.
期刊介绍：
This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of heart failure. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as investigative, pharmacologic, and nonpharmacologic therapies, pathophysiology, and prevention. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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