XACT-guided interventional procedures: A feasibility study

IF 3.2 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Medical physics Pub Date : 2026-04-05 DOI:10.1002/mp.70401

Yuchen Yan, Prabodh Kumar Pandey, Yifei Xu, Leshan Sun, Nadine Abi-Jaoudeh, Zhehui Wang, Shawn (Liangzhong) Xiang

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引用次数: 0

Abstract

Background

X-ray Induced Acoustic Computed Tomography (XACT) is an emerging imaging technique that provides 3D volumetric images from a single projection by detecting X-ray-induced acoustic (XA) waves with ultrasound (US) transducers. Unlike MRI or CT, XACT enables real-time 3D imaging without long acquisition times, 2D limitations, or motion artifacts from mechanical rotation. Furthermore, when integrated with conventional pulse-echo US through time-sequenced operation, XACT provides complementary soft-tissue contrast, establishing it as a promising platform for dynamic interventional radiology (IR) guidance.

Purpose

This study aims to evaluate the feasibility of XACT as a novel imaging tool for IR, specifically for guiding needle placement and monitoring contrast agent dynamics.

Methods

We developed a 3D XACT imaging system equipped with a 256-element 2D matrix array and a portable X-ray tube to visualize needle insertion and contrast agent dynamics. To capture both needle position and soft tissue anatomy, we integrated a dual-modality system combining XACT with pulse-echo US using a 128-element linear US array. Experiments were conducted on both tissue-mimic phantoms and soft tissue samples. GPU-accelerated algorithm has been developed for 3D XACT image reconstruction.

Results

The results demonstrate the 3D capabilities of XACT imaging for interventional procedures, including monitoring of needle placement and tracking of contrast agent dynamics. The imaging speed reached up to 3∼4 s per frame, constrained by the repetition rate of the X-ray source and signal to noise ratio. The dual-modality approach provided clear visualization of the needle's position and the surrounding soft tissue structures, achieving imaging resolution around 2 mm.

Conclusions

This study demonstrates that XACT imaging is feasible to be used for IR. Its 3D imaging capability with faster imaging speed would be an alternative to cone beam CT and its capability to combine US imaging will provide richer information for soft tissue

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xact引导的介入手术：可行性研究

背景：x射线诱发声计算机断层扫描（XACT）是一种新兴的成像技术，通过超声换能器检测x射线诱发声（XA）波，从单个投影中提供3D体积图像。与MRI或CT不同，XACT能够实现实时3D成像，没有长时间的采集时间、2D限制或机械旋转产生的运动伪影。此外，当通过时间序列操作与常规脉冲回波US结合时，XACT提供了互补的软组织对比，使其成为动态介入放射学（IR）指导的有前途的平台。目的：本研究旨在评估XACT作为一种新型红外成像工具的可行性，特别是用于引导针头放置和监测造影剂动态。方法：我们研制了一种三维XACT成像系统，该系统配备256单元二维矩阵阵列和便携式x射线管，用于显示针的插入和造影剂的动态。为了捕捉针的位置和软组织解剖结构，我们使用128单元线性超声阵列将XACT与脉冲回波超声相结合的双模系统集成在一起。实验分别在模拟组织模型和软组织样本上进行。提出了一种基于gpu加速的三维XACT图像重建算法。结果：结果证明了XACT成像在介入手术中的3D功能，包括监测针头放置和跟踪造影剂动态。受x射线源重复率和信噪比的限制，成像速度达到每帧3 ~ 4秒。双模态入路提供了针的位置和周围软组织结构的清晰可视化，成像分辨率约为2 mm。结论：本研究表明XACT成像用于红外是可行的。其3D成像能力和更快的成像速度将成为锥束CT的替代品，其结合超声成像的能力将为软组织提供更丰富的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical physics 医学-核医学

CiteScore

6.80

自引率

15.80%

发文量

660

审稿时长

1.7 months

期刊介绍： Medical Physics publishes original, high impact physics, imaging science, and engineering research that advances patient diagnosis and therapy through contributions in 1) Basic science developments with high potential for clinical translation 2) Clinical applications of cutting edge engineering and physics innovations 3) Broadly applicable and innovative clinical physics developments Medical Physics is a journal of global scope and reach. By publishing in Medical Physics your research will reach an international, multidisciplinary audience including practicing medical physicists as well as physics- and engineering based translational scientists. We work closely with authors of promising articles to improve their quality.