Cutaneous and serological profiles of idiopathic inflammatory myopathies in a hispanic population

Reumatologia clinica Pub Date : 2026-03-01 Epub Date: 2026-04-01 DOI:10.1016/j.reumae.2026.502100

Selene Maribel Delgado-Ayala , Sonia Chávez-Álvarez , Jorge Ocampo-Candiani , Miguel Ángel Villarreal-Alarcón , Dionicio Ángel Galarza-Delgado , Lourdes Gil-Flores , David Vega-Morales

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Abstract

Introduction

In the diagnosis and management of idiopathic inflammatory myopathies, cutaneous manifestations are particularly significant. Clinical signs are often associated with specific autoantibodies and play a role in the classification, treatment, and prognosis of IIM.

Objective

Describe the cutaneous clinical presentation, phototype, and autoantibody profiles among Hispanic patients with IIM.

Methods

A cross-sectional study was conducted from January 2015 to November 2022, including 64 patients diagnosed with IIM. Rheumatological and dermatological evaluations were performed, assessing Fitzpatrick phototype and Cutaneous Dermatomyositis Activity and Severity Index (CDASI) scores. Autoantibodies were analyzed using immunoblotting.

Results

Dermatomyositis (DM) was the most common subtype (73.4%). Fitzpatrick phototypes IV (59.4%) and III (37.5%) predominated. CDASI scores indicated mild dermatological activity in 60.9% of cases. Cluster analysis identified four patient groups with distinct clinical and serological profiles.

Conclusion

IIM have a complex disease expression. Recognizing its heterogeneities can enhance personalized treatment approaches.

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西班牙裔人群中特发性炎性肌病的皮肤和血清学特征。

在特发性炎性肌病的诊断和治疗中，皮肤表现尤为重要。临床体征往往与特异性自身抗体相关，在IIM的分类、治疗和预后中起着重要作用。目的：描述西班牙裔IIM患者的皮肤临床表现、光型和自身抗体谱。方法：对2015年1月至2022年11月诊断为IIM的64例患者进行横断面研究。进行风湿病学和皮肤病学评估，评估Fitzpatrick光型和皮肤皮肌炎活动和严重程度指数（CDASI）评分。免疫印迹法分析自身抗体。结果：皮肌炎（DM）是最常见的亚型（73.4%）。Fitzpatrick光型IV（59.4%）和III（37.5%）占多数。CDASI评分显示60.9%的病例有轻度皮肤活动。聚类分析确定了四组具有不同临床和血清学特征的患者。结论：IIM具有复杂的疾病表达。认识到其异质性可以提高个性化的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Reumatologia clinica

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