The role of transbronchial lung cryobiopsy in multidisciplinary discussion for interstitial lung diseases: a dual-center retrospective study.

IF 3 3区医学 Q2 RESPIRATORY SYSTEM

Therapeutic Advances in Respiratory Disease Pub Date : 2026-01-01 Epub Date: 2026-04-03 DOI:10.1177/17534666261438213

Qi Liu, Ting Wang, Qing Chang, Ning Xu, Ruolin Mao, Mengnan Li, Ding Sun, Yuqing Chen, Hai Zhang, Hongying Zhang, Feng Li

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引用次数: 0

Abstract

Background: Interstitial lung diseases (ILDs) are a heterogeneous group of disorders with complex etiologies and nonspecific clinical manifestations, often requiring histopathological confirmation for accurate diagnosis. Transbronchial lung cryobiopsy (TBLC) has emerged as a less invasive alternative to surgical lung biopsy (SLB) for obtaining lung tissue, yet its role in multidisciplinary discussion (MDD) remains underevaluated.

Objectives: This study aimed to assess the diagnostic yield and safety of TBLC when integrated into MDD for diagnosing ILDs.

Design: A retrospective dual-center study was conducted on 208 patients with undiagnosed ILDs who underwent TBLC at Shanghai Chest Hospital and Fuzhou Pulmonary Hospital from May 2021 to December 2024.

Methods: TBLC procedures were performed under general anesthesia, with samples evaluated by pathologists and integrated into MDD involving pulmonologists, radiologists, and rheumatologists. Diagnostic yield, complication rates, and concordance were analyzed.

Results: TBLC achieved a histological diagnostic yield of 88.9% (185/208 cases), which improved to 97.6% (203/208 cases) after MDD. The most common diagnosis was hypersensitivity pneumonitis (HP, 18.3%) followed by idiopathic nonspecific interstitial pneumonia (iNSIP, 15.4%). Complications were rare, with pneumothorax occurring in 5.3% of cases and moderate bleeding in 3.4%. No procedure-related mortality was observed.

Conclusion: TBLC is a safe and effective diagnostic tool for ILDs, with high diagnostic yield when integrated into MDD. TBLC reduces the need for SLB while maintaining low complication rates. These findings support TBLC as a valuable component of the MDD approach for ILDs.

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经支气管肺低温活检在间质性肺疾病多学科讨论中的作用：一项双中心回顾性研究。

背景：间质性肺疾病（ILDs）是一种异质性疾病，具有复杂的病因和非特异性的临床表现，通常需要组织病理学证实才能准确诊断。经支气管肺低温活检（TBLC）已成为外科肺活检（SLB）获得肺组织的一种侵入性较小的替代方法，但其在多学科讨论（MDD）中的作用仍被低估。目的：本研究旨在评估TBLC与MDD结合诊断ild的诊断率和安全性。设计：对2021年5月至2024年12月在上海胸科医院和福州肺科医院行TBLC的208例未确诊ild患者进行回顾性双中心研究。方法：TBLC手术在全麻下进行，由病理学家评估样本，并纳入包括肺科医生、放射科医生和风湿病医生在内的MDD。分析诊断率、并发症发生率和一致性。结果：TBLC的组织学诊断率为88.9%（185/208例），MDD后提高到97.6%（203/208例）。最常见的诊断是过敏性肺炎（HP, 18.3%），其次是特发性非特异性间质性肺炎（iNSIP, 15.4%）。并发症很少，5.3%的病例发生气胸，3.4%的病例发生中度出血。未观察到手术相关的死亡率。结论：TBLC是一种安全有效的ild诊断工具，结合MDD具有较高的诊断率。TBLC减少了SLB的需要，同时保持了低并发症发生率。这些发现支持TBLC作为ILDs MDD方法的一个有价值的组成部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Advances in Respiratory Disease RESPIRATORY SYSTEM-

CiteScore

6.90

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Therapeutic Advances in Respiratory Disease delivers the highest quality peer-reviewed articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of respiratory disease.