{"title":"Severe Cyanoacrylate Granuloma Following Cyanoacrylate Closure for Varicose Veins in a Patient with Immune Modulation: A Case Report.","authors":"Takahiro Imai, Daisuke Harada, Yoichi Mizutani, Soutarou Katsui","doi":"10.3400/avd.cr.25-00144","DOIUrl":null,"url":null,"abstract":"<p><p>We report a case of severe cyanoacrylate granuloma (CAG) that developed shortly after cyanoacrylate closure (CAC) in a patient receiving dupilumab. A 74-year-old female had an uneventful postoperative course until the day before initiation of dupilumab; however, on postoperative day (POD) 16, 1 day after starting dupilumab, she developed fever and painful inguinal nodules. Computed tomography revealed multiple subcutaneous nodules without abscess formation. Despite systemic corticosteroids and antihistamines, the lesions progressed, requiring repeated bilateral excisions through POD 93. This case suggests that immune modulation at the time of cyanoacrylate exposure may influence the severity and progression of granulomatous inflammation after CAC.</p>","PeriodicalId":7995,"journal":{"name":"Annals of vascular diseases","volume":"19 1","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043239/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of vascular diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3400/avd.cr.25-00144","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/3/31 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
引用次数: 0
Abstract
We report a case of severe cyanoacrylate granuloma (CAG) that developed shortly after cyanoacrylate closure (CAC) in a patient receiving dupilumab. A 74-year-old female had an uneventful postoperative course until the day before initiation of dupilumab; however, on postoperative day (POD) 16, 1 day after starting dupilumab, she developed fever and painful inguinal nodules. Computed tomography revealed multiple subcutaneous nodules without abscess formation. Despite systemic corticosteroids and antihistamines, the lesions progressed, requiring repeated bilateral excisions through POD 93. This case suggests that immune modulation at the time of cyanoacrylate exposure may influence the severity and progression of granulomatous inflammation after CAC.
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