Phenotypic Trends and Molecular Mechanisms of Helicobacter pylori Antibiotic Resistance in Bangladesh: A Scoping Review.

IF 2.6 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Tropical Medicine & International Health Pub Date : 2026-07-01 Epub Date: 2026-03-31 DOI:10.1111/tmi.70129

Mohammod K Islam, Ali Dway, Aasma Karki

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引用次数: 0

Abstract

Objective: To comprehensively map the phenotypic prevalence, temporal trends, and molecular mechanisms of antimicrobial resistance in Helicobacter pylori isolates among patients in Bangladesh.

Method: Scoping review conducted in accordance with the JBI methodology and reported using the PRISMA-ScR checklist. A systematic search was conducted in PubMed, MEDLINE, Scopus, and BanglaJOL to identify peer-reviewed observational studies published between 1 January 2000 and 30 April 2025.

Results: Ten studies were reviewed. Metronidazole resistance remained persistently high (77.5%-96.4%), while clarithromycin rates surged from ~10% to > 39%. Levofloxacin resistance also reached critical levels (up to 66.1%). In contrast, amoxicillin (< 10%) and tetracycline (< 20%) retained efficacy. Genomic analysis linked resistance primarily to 23S rRNA (A2142G, A2143G) and gyrA mutations within hpAsia2 and hpEurope lineages.

Conclusion: The available evidence indicates a high and increasing burden of H. pylori antibiotic resistance in Bangladesh, particularly to clarithromycin, metronidazole, and levofloxacin. These findings highlight the need for updated, evidence-informed treatment strategies and expanded molecular surveillance to support effective eradication therapy.

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孟加拉国幽门螺杆菌耐药性的表型趋势和分子机制：范围综述。

目的：全面绘制孟加拉国患者幽门螺杆菌分离株的表型患病率、时间趋势和抗微生物药物耐药性的分子机制。方法：根据JBI方法学进行范围审查，并使用PRISMA-ScR检查表进行报告。在PubMed、MEDLINE、Scopus和BanglaJOL中进行了系统检索，以确定2000年1月1日至2025年4月30日期间发表的同行评议观察性研究。结果：回顾了10项研究。甲硝唑耐药率居高不下（77.5% ~ 96.4%），克拉霉素耐药率从10% ~10%上升至39%。左氧氟沙星耐药也达到临界水平（高达66.1%）。结论：现有证据表明，孟加拉国幽门螺杆菌抗生素耐药负担很高，而且在不断增加，特别是对克拉霉素、甲硝唑和左氧氟沙星。这些发现强调需要更新循证治疗策略和扩大分子监测，以支持有效的根除治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tropical Medicine & International Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.80

自引率

0.00%

发文量

129

审稿时长

6 months

期刊介绍： Tropical Medicine & International Health is published on behalf of the London School of Hygiene and Tropical Medicine, Swiss Tropical and Public Health Institute, Foundation Tropical Medicine and International Health, Belgian Institute of Tropical Medicine and Bernhard-Nocht-Institute for Tropical Medicine. Tropical Medicine & International Health is the official journal of the Federation of European Societies for Tropical Medicine and International Health (FESTMIH).