A Risk Factor Atlas for Allergy-Related Airway Diseases: Evidence From Multi-Biobank Genetic Study.

IF 4.3 2区医学 Q2 ALLERGY

Allergy, Asthma & Immunology Research Pub Date : 2026-03-01 DOI:10.4168/aair.2026.18.2.224

Tao Guo, Peiyu Luo, Guobing Jia, Dehong Liu, Hui Xie

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引用次数: 0

Abstract

Purpose: Understanding factors contributing to allergy-related airway diseases (AADs).

Methods: We conducted a meta-analysis of Mendelian randomization (MR) estimates from multi-biobank to investigate the effects of 83 common factors on asthma, allergic rhinitis (AR), chronic rhinosinusitis (CRS), and nasal polyps (NPs). Data for AADs were obtained from multiple independent populations including FinnGen, UK Biobank and large consortia (asthma, 137,498 cases and 1,009,466 controls; AR, 51,712 cases and 592,784 controls; CRS, 24,688 cases and 760,073 controls; and NP, 11,796 cases and 760,075 controls). The meta-analyses combining the above multi-biobank MR results were employed as our main results.

Results: Genetically proxied social isolation, smoking time and frequency, sedentary time, global and central obesity, C-reactive protein (CRP), insomnia, major depressive disorder (MDD), anxiety, attention deficit hyperactivity disorder, neuroticism, posttraumatic stress disorder (PTSD), rheumatoid arthritis (RA), atopic dermatitis (AD), type 1 diabetes (T1D), gastroesophageal reflux disease (GERD), childhood obesity, early menarche, smoking around birth, and childhood maltreatment could increase the risk of asthma. Education, higher income, cheese intake, sleep duration, high density lipoprotein cholesterol, forced expiratory volume in 1 second/forced vital capacity, well-being and ulcerative colitis were associated with a decreased risk of asthma. Social isolation, CRP, Crohn's disease, GERD, insomnia, MDD, neuroticism and AD could increase the risk of AR, whereas well-being could decrease the risk of AR. Sedentary time, MDD, anxiety, PTSD, opioid use disorder, RA, AD, T1D, hypothyroidism, and GERD could increase the risk of CRS, whereas coffee intake, apolipoprotein A1, and well-being were associated with a decreased risk of CRS. Smoking duration, RA, AD and T1D could increase the risk of NP, whereas fresh fruit intake could decrease the risk of NP.

Conclusions: This study offers potential causal evidence for AAD risk factors and provides actionable targets for primary prevention.

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过敏症相关气道疾病的危险因素图谱：来自多生物库遗传研究的证据

目的：了解过敏性气道疾病（AADs）的相关因素。方法：我们对来自多生物库的孟德尔随机化（MR）估计进行了荟萃分析，以调查83种常见因素对哮喘、变应性鼻炎（AR）、慢性鼻窦炎（CRS）和鼻息肉（NPs）的影响。AADs的数据来自多个独立人群，包括FinnGen、UK Biobank和大型联盟（哮喘，137,498例和1,009,466例对照；AR, 51,712例和592,784例对照；CRS, 24,688例和760,073例对照；NP, 11,796例和760,075例对照）。综合以上多生物库MR结果的meta分析作为我们的主要结果。结果:与基因相关的社会孤立、吸烟时间和频率、久坐时间、全身性和中枢性肥胖、c -反应蛋白（CRP）、失眠、重度抑郁症（MDD）、焦虑、注意力缺陷多动障碍、神经质、创伤后应激障碍（PTSD）、类风湿性关节炎（RA）、特应性皮炎（AD）、1型糖尿病（T1D）、胃食管反流病（GERD）、儿童肥胖、月经初潮提前、分娩前后吸烟、儿童虐待可能会增加患哮喘的风险。受教育程度、高收入、奶酪摄入量、睡眠时间、高密度脂蛋白胆固醇、1秒用力呼气量/用力肺活量、健康状况和溃疡性结肠炎与哮喘风险降低相关。社会孤立、CRP、克罗恩病、GERD、失眠、重度抑郁症、神经质和AD可增加AR的风险，而幸福感可降低AR的风险。久坐、MDD、焦虑、创伤后应激障碍、阿片类药物使用障碍、RA、AD、T1D、甲状腺功能减退和GERD可增加CRS的风险，而咖啡摄入量、载脂蛋白A1和幸福感与CRS风险降低相关。吸烟时间、RA、AD和T1D可增加NP风险，而新鲜水果摄入可降低NP风险。结论：本研究为AAD危险因素提供了潜在的因果证据，并为初级预防提供了可操作的目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergy, Asthma & Immunology Research ALLERGY-IMMUNOLOGY

CiteScore

6.10

自引率

6.80%

发文量

审稿时长

>12 weeks

期刊介绍： The journal features cutting-edge original research, brief communications, and state-of-the-art reviews in the specialties of allergy, asthma, and immunology, including clinical and experimental studies and instructive case reports. Contemporary reviews summarize information on topics for researchers and physicians in the fields of allergy and immunology. As of January 2017, AAIR do not accept case reports. However, if it is a clinically important case, authors can submit it in the form of letter to the Editor. Editorials and letters to the Editor explore controversial issues and encourage further discussion among physicians dealing with allergy, immunology, pediatric respirology, and related medical fields. AAIR also features topics in practice and management and recent advances in equipment and techniques for clinicians concerned with clinical manifestations of allergies and pediatric respiratory diseases.