Inflammatory Bowel Disease Incidence following COVID-19: A Systematic Review and Meta-Analysis.

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY

GE Portuguese Journal of Gastroenterology Pub Date : 2026-02-11 eCollection Date: 2026-01-01 DOI:10.1159/000550703

Aris P Agouridis, Alexandros Hadjivasilis, Georgios Vougiouklakis, Theognosia Ioannou, Stavria Charitonos, Marios Christoforou, Evangelos Ionas, Dimitrios Giannakakis, Nikolaos Spernovasilis

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引用次数: 0

Abstract

Background: A surge of cases of autoimmune and inflammatory diseases, such as inflammatory bowel disease (IBD), have been reported after coronavirus disease 2019 (COVID-19).

Objective: The objective of this study was to assess whether COVID-19 has a role in IBD risk.

Methods: We searched MEDLINE (PubMed), Cochrane Library and OpenGrey databases up to October 30, 2025, for studies evaluating the incidence of IBD following COVID-19 infection (PROSPERO ID: CRD42024534916).

Results: After a full-text review of 84 manuscripts, a total of 8 studies were used in the qualitative analysis. The studies were conducted between 2023 and 2024 and included in total 28,659,801 people, 8,560,826 of which were previously infected with COVID-19 and 20,098,975 that served as healthy controls. The results from the pooled synthesis of 6 studies indicate a 39% higher incidence of IBD in people that were previously infected with COVID-19 (risk ratio [RR] 1.39, 95% CI: [1.12-1.74], p = 0.003, I ² = 97%). Furthermore, from the pooled analysis of 4 eligible studies, a higher incidence of new ulcerative colitis cases following COVID-19 was observed (RR 1.25, 95% CI: [1.17-1.33], p < 0.00001, I ² = 0%). On the contrary, no difference was observed in Crohn's disease incidence between COVID-19 and non-COVID-19 patients (RR 1.23 95% CI: [0.88, 1.72], p = 0.22, I ² = 91%).

Conclusions: The findings of the present meta-analysis suggest an increased risk of IBD after COVID-19 infection. Although this is more evident regarding ulcerative colitis, we believe that the available outcomes arising from future studies will clarify the real incidence of Crohn's disease following COVID-19 infection.

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查看原文本刊更多论文

COVID-19后炎症性肠病发病率：系统综述和荟萃分析

背景：在2019冠状病毒病（COVID-19）之后，报告了大量自身免疫性和炎症性疾病，如炎症性肠病（IBD）。目的：本研究的目的是评估COVID-19是否在IBD风险中起作用。方法：我们检索MEDLINE （PubMed）、Cochrane Library和OpenGrey数据库，检索截至2025年10月30日的评估COVID-19感染后IBD发生率的研究（PROSPERO ID: CRD42024534916）。结果：通过对84篇论文的全文审阅，共纳入8项研究进行定性分析。这些研究在2023年至2024年期间进行，共纳入28659801人，其中8560826人以前感染过COVID-19, 20098975人作为健康对照。6项研究的综合结果显示，先前感染过COVID-19的人群IBD发病率增加39%（风险比[RR] 1.39, 95% CI: [1.12-1.74], p = 0.003, i2 = 97%）。此外，从4项符合条件的研究的汇总分析中，观察到COVID-19后溃疡性结肠炎新发病例的发生率更高（RR 1.25, 95% CI: [1.17-1.33], p < 0.00001, I 2 = 0%）。相反，COVID-19患者与非COVID-19患者的克罗恩病发病率无差异（RR 1.23 95% CI: [0.88, 1.72], p = 0.22, i2 = 91%）。结论：本荟萃分析的结果表明，COVID-19感染后IBD的风险增加。虽然这在溃疡性结肠炎方面更为明显，但我们相信，未来研究的现有结果将澄清COVID-19感染后克罗恩病的真实发病率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

GE Portuguese Journal of Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

1.60

自引率

11.10%

发文量

审稿时长

21 weeks

期刊介绍： The ''GE Portuguese Journal of Gastroenterology'' (formerly Jornal Português de Gastrenterologia), founded in 1994, is the official publication of Sociedade Portuguesa de Gastrenterologia (Portuguese Society of Gastroenterology), Sociedade Portuguesa de Endoscopia Digestiva (Portuguese Society of Digestive Endoscopy) and Associação Portuguesa para o Estudo do Fígado (Portuguese Association for the Study of the Liver). The journal publishes clinical and basic research articles on Gastroenterology, Digestive Endoscopy, Hepatology and related topics. Review articles, clinical case studies, images, letters to the editor and other articles such as recommendations or papers on gastroenterology clinical practice are also considered. Only articles written in English are accepted.