{"title":"Energetics for Hydrogen Atom Transfer by Ketyl Radicals: Is Thermodynamics on Your Side?","authors":"Juan C. Scaiano","doi":"10.1002/poc.70076","DOIUrl":null,"url":null,"abstract":"<p>Ketyl radicals play a key role in various reaction mechanisms, where their ability to donate hydrogen atoms governs numerous processes, ranging from photoredox catalysis to biological mechanisms and the synthesis of metal nanoparticles. Despite their significance, the thermochemical parameters that dictate their behavior remain poorly understood, leading to many inconsistencies in the literature. This minireview aims to provide a comprehensive perspective, addressing these inconsistencies that only emerge when comparing a family of reactions where available data challenge our understanding of chemical reactivity. The tables presented here, in combination with other resources, offer a robust and consistent reactivity paradigm that aligns well with the experimental reactivity of ketyl radicals.</p>","PeriodicalId":16829,"journal":{"name":"Journal of Physical Organic Chemistry","volume":"39 4","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/poc.70076","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Physical Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/poc.70076","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Ketyl radicals play a key role in various reaction mechanisms, where their ability to donate hydrogen atoms governs numerous processes, ranging from photoredox catalysis to biological mechanisms and the synthesis of metal nanoparticles. Despite their significance, the thermochemical parameters that dictate their behavior remain poorly understood, leading to many inconsistencies in the literature. This minireview aims to provide a comprehensive perspective, addressing these inconsistencies that only emerge when comparing a family of reactions where available data challenge our understanding of chemical reactivity. The tables presented here, in combination with other resources, offer a robust and consistent reactivity paradigm that aligns well with the experimental reactivity of ketyl radicals.
期刊介绍：
The Journal of Physical Organic Chemistry is the foremost international journal devoted to the relationship between molecular structure and chemical reactivity in organic systems. It publishes Research Articles, Reviews and Mini Reviews based on research striving to understand the principles governing chemical structures in relation to activity and transformation with physical and mathematical rigor, using results derived from experimental and computational methods. Physical Organic Chemistry is a central and fundamental field with multiple applications in fields such as molecular recognition, supramolecular chemistry, catalysis, photochemistry, biological and material sciences, nanotechnology and surface science.
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