{"title":"Microwave-Assisted Hantzsch, Biginelli, and GBB Reactions: Eco-Efficient Synthesis of N-Heterocycles","authors":"Divyani P. Patel, Satish Kumar Singh","doi":"10.1002/jhet.70139","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>As we look to the future, it is important to remember the significance of assessing the efficiency of multicomponent reactions (MCRs) of green chemistry principles. These reactions have a favorable compatibility with environmentally friendly organic synthesis. N-heterocyclic moieties are highly regarded and play a crucial role in modern organic chemistry. Looking ahead, Hantzsch, Biginelli, and GBB MCRs with microwave-assisted chemistry approaches promise to significantly reduce chemical waste and reaction times. These methods quickly and effectively incorporate numerous structurally diverse aspects into heterocyclic compounds, all accomplished in a single synthetic step. Anticipating the need to produce biologically active heterocyclic compounds in the future, MW-assisted MCRs (Hantzsch, Biginelli, and GBB) could become important green synthesis methods.</p>\n </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"63 3","pages":"432-453"},"PeriodicalIF":2.9000,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Heterocyclic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jhet.70139","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/12/2 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
As we look to the future, it is important to remember the significance of assessing the efficiency of multicomponent reactions (MCRs) of green chemistry principles. These reactions have a favorable compatibility with environmentally friendly organic synthesis. N-heterocyclic moieties are highly regarded and play a crucial role in modern organic chemistry. Looking ahead, Hantzsch, Biginelli, and GBB MCRs with microwave-assisted chemistry approaches promise to significantly reduce chemical waste and reaction times. These methods quickly and effectively incorporate numerous structurally diverse aspects into heterocyclic compounds, all accomplished in a single synthetic step. Anticipating the need to produce biologically active heterocyclic compounds in the future, MW-assisted MCRs (Hantzsch, Biginelli, and GBB) could become important green synthesis methods.
期刊介绍：
The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.
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