[General toxic and organotropic properties of azlocillin in acute and chronic experiments].

Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology Pub Date : 1987-06-01

V V Berezhinskaia, G V Dolgova, G G Egorenko, T P Svinogeeva, L A Shtegel'man

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Abstract

The general toxic and organotropic properties of azlocillin were studied in acute and chronic experiments with various animal species. By the body surface area the doses of azlocillin were equivalent to the drug average and maximum course doses for humans. The aim of the study was to determine the drug dose inducing certain side effects. It was found that only in a dose equivalent to the maximum course dose for humans i. e. 300 g the drug induced a transient increase in the blood levels of aspartate aminotransferase and alkaline phosphatase and some increase in the coagulation time. The allergenic properties of the drug were slightly pronounced. Within the tested doses azlocillin did not affect the peripheral blood indices and showed no immunomodulating embryotoxic, teratogenic or mutagenic effect. The experimental data indicated that the range between the drug therapeutic course doses and the doses inducing certain side effects was significant. This is evidence of a sufficiently high level of azlocillin safety.

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[急性和慢性实验中唑洛西林的一般毒性和嗜器官性质]。

在不同动物的急、慢性实验中，研究了唑洛西林的一般毒性和嗜器官性。按体表面积计算，唑洛西林的剂量相当于人体的药物平均和最大疗程剂量。研究的目的是确定引起某些副作用的药物剂量。结果发现，只有在相当于人体最大疗程剂量(即300 g)的剂量下，该药才会引起血液中天冬氨酸转氨酶和碱性磷酸酶水平的短暂升高，并使凝血时间有所延长。这种药的致敏性有点明显。在试验剂量内，唑洛西林不影响外周血指标，无免疫调节、胚胎毒性、致畸或致突变作用。实验数据表明，药物治疗过程剂量与引起某些副作用的剂量之间的范围是显著的。这证明了唑洛西林具有足够高的安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology

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