Intraocular pressure distribution in old and young cynomolgus monkeys following general anesthesia and mydriasis.

IF 1.8 3区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Vision Pub Date : 2025-09-28 eCollection Date: 2025-01-01

Jinan Zhan, Zhidong Li, Guitong Ye, Yuan Zhang, Kezhe Chen, Rui Xie, Wei Liu, Jian Wu, Yingting Zhu, Yehong Zhuo

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引用次数: 0

Abstract

Purpose: To investigate the intraocular pressure (IOP) distribution of cynomolgus monkeys in different age groups after anesthesia and mydriasis.

Methods: A total of 158 young and 252 old cynomolgus monkeys, aged 3.95 (1.61; range, 1.38 to 5.97) and 18.80 (1.67; range, 15.21 to 24.69) years, respectively, were subjected to general anesthesia (intramuscular injection of Zoletil 4 mg/kg mixed with xylazine/ketamine 0.2 mg/kg). IOP was measured using an Icare tonometer at three time points: immediately following the onset of anesthesia, after stabilization but before mydriasis, and after mydriasis (induced by 1% tropicamide eye drops).

Results: No significant differences were observed between sexes or between eyes within the Macaca fascicularis colony. After anesthesia stabilization but before mydriasis, the IOP of the old M. fascicularis colony was 22.33 mm Hg (4.12; range, 12.33 to 37.33), whereas the IOP of the young M. fascicularis colony was 16.67 mm Hg (4.00; range, 10.67 to 25.67). After mydriasis, the IOP of the old M. fascicularis colony was 19.33 mm Hg (5.00; range 11.33 to 33.00), while the IOP of the young M. fascicularis colony was 15.67 mm Hg (4.50; range, 9.67 to 24.00). All measurements were conducted with the monkeys in a prone position. Notably, both the young and old colonies experienced a significant decrease in IOP after mydriasis (p < 0.001). Moreover, the reduction observed in the young colony was significantly greater than that in the old colony (p < 0.001).

Conclusions: The IOP levels of the old M. fascicularis colony were higher than those of the young one, regardless of whether it was after anesthesia, before mydriasis, or after mydriasis. Furthermore, monkeys of different age groups had different reductions in IOP under different interventions (anesthesia, mydriasis). Additionally, within the M. fascicularis colony, IOP was equivalent between males and females, as well as between the right and left eyes.

本刊更多论文

老年和年轻食蟹猴在全身麻醉和抽丝后的眼压分布。

目的：观察不同年龄组食蟹猴麻醉和吸蝇后眼压的分布。方法：选取年龄3.95岁（1.61岁，范围1.38 ~ 5.97岁）和18.80岁（1.67岁，范围15.21 ~ 24.69岁）的幼食猴158只和老年食蟹猴252只进行全身麻醉（肌内注射唑来替尔4mg /kg与氯胺酮/噻嗪0.2 mg/kg混合）。使用Icare眼压计在三个时间点测量IOP：麻醉开始后立即，稳定后但散瞳前，散瞳后（1% tropicamide滴眼液诱导）。结果：在束状猕猴群体中，性别和眼间无显著差异。麻醉稳定后吸丝前，老年束状支原体眼压为22.33 mm Hg(4.12，范围12.33 ~ 37.33)，年轻束状支原体眼压为16.67 mm Hg（4.00，范围10.67 ~ 25.67）。吸丝后，老年虫群眼压为19.33 mm Hg(5.00，范围11.33 ~ 33.00)，幼年虫群眼压为15.67 mm Hg（4.50，范围9.67 ~ 24.00）。所有测量都是在猴子俯卧的情况下进行的。值得注意的是，年轻和年老的菌落在虫眼后眼压都显著下降（p < 0.001）。此外，在年轻群体中观察到的减少显著大于老年群体（p < 0.001）。结论：不论是麻醉后、吸丝前还是吸丝后，老年束状支原体的IOP水平均高于幼龄束状支原体。此外，不同年龄组的猴子在不同的干预措施（麻醉、吸眼液）下的眼压下降也不同。此外，在束状斑蝶群体中，雄性和雌性以及右眼和左眼之间的IOP是相等的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Vision 生物-生化与分子生物学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Molecular Vision is a peer-reviewed journal dedicated to the dissemination of research results in molecular biology, cell biology, and the genetics of the visual system (ocular and cortical). Molecular Vision publishes articles presenting original research that has not previously been published and comprehensive articles reviewing the current status of a particular field or topic. Submissions to Molecular Vision are subjected to rigorous peer review. Molecular Vision does NOT publish preprints. For authors, Molecular Vision provides a rapid means of communicating important results. Access to Molecular Vision is free and unrestricted, allowing the widest possible audience for your article. Digital publishing allows you to use color images freely (and without fees). Additionally, you may publish animations, sounds, or other supplementary information that clarifies or supports your article. Each of the authors of an article may also list an electronic mail address (which will be updated upon request) to give interested readers easy access to authors.