Retrospective Analysis of Burden of Illness of Congenital Pulmonary Valve Disease in a Large, Commercially Insured US Population.

IF 2.3 Q2 ECONOMICS

Journal of Health Economics and Outcomes Research Pub Date : 2026-03-19 eCollection Date: 2026-01-01 DOI:10.36469/001c.156168

Tariku J Beyene, Vincent J Willey, Malvika Venkataraman, Katherine Wong, Eric Anderson, Sophie C Hofferberth

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Mean annual costs for each age group were multiplied by age category duration to estimate full age category period costs. Costs for each age category period were summed to estimate lifetime costs through 65 years of age. Sensitivity analyses were conducted in subgroups with continuous eligibility from birth through 60 months and 120 months.Results: Among eligible patients (N = 22 751), 53.2% experienced an average of 1.8 CPVD-related inpatient admissions during their first year: mean (standard deviation) cumulative admission days, 50.2 (74.2); with <math><mn>267</mn> <mrow><mo> </mo></mrow> <mn>945</mn> <mo>(</mo> <mn>737</mn> <mrow><mo> </mo></mrow> <mn>565</mn> <mo>;</mo> <mi>m</mi> <mi>e</mi> <mi>d</mi> <mi>i</mi> <mi>a</mi> <mi>n</mi> <mo>,</mo> <mn>6487</mn> <mo>[</mo> <mi>i</mi> <mi>n</mi> <mi>t</mi> <mi>e</mi> <mi>r</mi> <mi>q</mi> <mi>u</mi> <mi>a</mi> <mi>r</mi> <mi>t</mi> <mi>i</mi> <mi>l</mi> <mi>e</mi> <mi>r</mi> <mi>a</mi> <mi>n</mi> <mi>g</mi> <mi>e</mi> <mo>(</mo> <mi>I</mi> <mi>Q</mi> <mi>R</mi> <mo>)</mo> <mo>,</mo> <mn>0</mn> <mo>-</mo> <mn>238</mn> <mrow><mo> </mo></mrow> <mn>486</mn> <mo>]</mo> <mi>i</mi> <mi>n</mi> <mi>a</mi> <mi>s</mi> <mi>s</mi> <mi>o</mi> <mi>c</mi> <mi>i</mi> <mi>a</mi> <mi>t</mi> <mi>e</mi> <mi>d</mi> <mi>c</mi> <mi>o</mi> <mi>s</mi> <mi>t</mi> <mi>s</mi> <mo>.</mo> <mi>A</mi> <mi>m</mi> <mi>o</mi> <mi>n</mi> <mi>g</mi> <mi>t</mi> <mi>h</mi> <mi>o</mi> <mi>s</mi> <mi>e</mi> <mi>w</mi> <mi>i</mi> <mi>t</mi> <mi>h</mi> <mi>i</mi> <mi>n</mi> <mi>p</mi> <mi>a</mi> <mi>t</mi> <mi>i</mi> <mi>e</mi> <mi>n</mi> <mi>t</mi> <mi>a</mi> <mi>d</mi> <mi>m</mi> <mi>i</mi> <mi>s</mi> <mi>s</mi> <mi>i</mi> <mi>o</mi> <mi>n</mi> <mi>s</mi> <mi>f</mi> <mi>o</mi> <mi>r</mi> <mi>C</mi> <mi>P</mi> <mi>V</mi> <mi>D</mi> <mo>-</mo> <mi>r</mi> <mi>e</mi> <mi>l</mi> <mi>a</mi> <mi>t</mi> <mi>e</mi> <mi>d</mi> <mi>p</mi> <mi>r</mi> <mi>o</mi> <mi>c</mi> <mi>e</mi> <mi>d</mi> <mi>u</mi> <mi>r</mi> <mi>e</mi> <mi>s</mi> <mi>d</mi> <mi>u</mi> <mi>r</mi> <mi>i</mi> <mi>n</mi> <mi>g</mi> <mi>c</mi> <mi>h</mi> <mi>i</mi> <mi>l</mi> <mi>d</mi> <mi>h</mi> <mi>o</mi> <mi>o</mi> <mi>d</mi> <mo>,</mo> <mi>a</mi> <mi>v</mi> <mi>e</mi> <mi>r</mi> <mi>a</mi> <mi>g</mi> <mi>e</mi> <mi>a</mi> <mi>n</mi> <mi>n</mi> <mi>u</mi> <mi>a</mi> <mi>l</mi> <mi>c</mi> <mi>o</mi> <mi>s</mi> <mi>t</mi> <mi>s</mi> <mi>r</mi> <mi>a</mi> <mi>n</mi> <mi>g</mi> <mi>e</mi> <mi>d</mi> <mi>f</mi> <mi>r</mi> <mi>o</mi> <mi>m</mi></math> 97 791 (288 606; 32 029 [15 984-72 762]) to <math><mn>514</mn> <mrow><mo> </mo></mrow> <mn>395</mn> <mo>(</mo> <mn>926</mn> <mrow><mo> </mo></mrow> <mn>572</mn> <mo>;</mo> <mn>222</mn> <mrow><mo> </mo></mrow> <mn>373</mn> <mo>[</mo> <mn>114</mn> <mrow><mo> </mo></mrow> <mn>107</mn> <mo>-</mo> <mn>530</mn> <mrow><mo> </mo></mrow> <mn>671</mn> <mo>]</mo> <mi>b</mi> <mi>y</mi> <mi>a</mi> <mi>g</mi> <mi>e</mi> <mi>c</mi> <mi>a</mi> <mi>t</mi> <mi>e</mi> <mi>g</mi> <mi>o</mi> <mi>r</mi> <mi>y</mi> <mo>.</mo> <mi>E</mi> <mi>m</mi> <mi>e</mi> <mi>r</mi> <mi>g</mi> <mi>e</mi> <mi>n</mi> <mi>c</mi> <mi>y</mi> <mi>d</mi> <mi>e</mi> <mi>p</mi> <mi>a</mi> <mi>r</mi> <mi>t</mi> <mi>m</mi> <mi>e</mi> <mi>n</mi> <mi>t</mi> <mi>u</mi> <mi>t</mi> <mi>i</mi> <mi>l</mi> <mi>i</mi> <mi>z</mi> <mi>a</mi> <mi>t</mi> <mi>i</mi> <mi>o</mi> <mi>n</mi> <mi>r</mi> <mi>a</mi> <mi>n</mi> <mi>g</mi> <mi>e</mi> <mi>d</mi> <mi>b</mi> <mi>e</mi> <mi>t</mi> <mi>w</mi> <mi>e</mi> <mi>e</mi> <mi>n</mi> <mn>8</mn></math> 59 537 (111 982; 13 690 [918-66 625]) and 120 months (N = 174) at <math><mn>28</mn> <mrow><mo> </mo></mrow> <mn>893</mn> <mo>(</mo> <mn>69</mn> <mrow><mo> </mo></mrow> <mn>019</mn> <mo>;</mo> <mn>2852</mn> <mo>[</mo> <mn>400</mn> <mo>-</mo> <mn>23</mn> <mrow><mo> </mo></mrow> <mn>858</mn> <mo>]</mo> <mo>)</mo> <mo>.</mo> <mi>B</mi> <mi>y</mi> <mi>a</mi> <mi>g</mi> <mi>e</mi> <mn>21</mn> <mo>,</mo> <mi>p</mi> <mi>r</mi> <mi>o</mi> <mi>j</mi> <mi>e</mi> <mi>c</mi> <mi>t</mi> <mi>e</mi> <mi>d</mi> <mi>c</mi> <mi>u</mi> <mi>m</mi> <mi>u</mi> <mi>l</mi> <mi>a</mi> <mi>t</mi> <mi>i</mi> <mi>v</mi> <mi>e</mi> <mi>C</mi> <mi>P</mi> <mi>V</mi> <mi>D</mi> <mo>-</mo> <mi>r</mi> <mi>e</mi> <mi>l</mi> <mi>a</mi> <mi>t</mi> <mi>e</mi> <mi>d</mi> <mi>m</mi> <mi>e</mi> <mi>d</mi> <mi>i</mi> <mi>c</mi> <mi>a</mi> <mi>l</mi> <mi>c</mi> <mi>o</mi> <mi>s</mi> <mi>t</mi> <mi>s</mi> <mi>a</mi> <mi>v</mi> <mi>e</mi> <mi>r</mi> <mi>a</mi> <mi>g</mi> <mi>e</mi> <mi>d</mi></math> 788 188 and reached $2.1 million through age 65. 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引用次数: 0

Abstract

Background: Babies born with congenital pulmonary valve disease (CPVD) face a lifetime burden of disease and significant medical expense beginning in their first year of life.

Objectives: To assess costs and burden of care in patients with CPVD from birth through age 65.

Methods: This retrospective study used administrative claims data to examine healthcare costs and utilization among commercially insured patients with ≥2 claims with CPVD diagnosis between January 1, 2006, and April 30, 2024; the earliest CPVD claim defined the index date. Per-patient-per-year costs were calculated by age category. Mean annual costs for each age group were multiplied by age category duration to estimate full age category period costs. Costs for each age category period were summed to estimate lifetime costs through 65 years of age. Sensitivity analyses were conducted in subgroups with continuous eligibility from birth through 60 months and 120 months.

Results: Among eligible patients (N = 22 751), 53.2% experienced an average of 1.8 CPVD-related inpatient admissions during their first year: mean (standard deviation) cumulative admission days, 50.2 (74.2); with $267 945 (737 565; m e d i a n, 6487 [i n t e r q u a r t i l e r a n g e (I Q R), 0 - 238 486] i n a s s o c i a t e d c o s t s . A m o n g t h o s e w i t h i n p a t i e n t a d m i s s i o n s f o r C P V D - r e l a t e d p r o c e d u r e s d u r i n g c h i l d h o o d, a v e r a g e a n n u a l c o s t s r a n g e d f r o m$ 97 791 (288 606; 32 029 [15 984-72 762]) to $514 395 (926 572; 222 373 [114 107 - 530 671] b y a g e c a t e g o r y . E m e r g e n c y d e p a r t m e n t u t i l i z a t i o n r a n g e d b e t w e e n 8$ 59 537 (111 982; 13 690 [918-66 625]) and 120 months (N = 174) at $28 893 (69 019; 2852 [400 - 23 858]) . B y a g e 21, p r o j e c t e d c u m u l a t i v e C P V D - r e l a t e d m e d i c a l c o s t s a v e r a g e d$ 788 188 and reached $2.1 million through age 65. Over half of patients had nearly 2 months of hospital stays in their first year, with substantial inpatient costs. The financial burden and demanding care began early and remained steady, reflecting the chronic nature of CPVD.

Conclusion: This study demonstrates a substantial burden of illness and lifetime mosaic of ongoing medical needs for individuals with CPVD and the potential for advances in early life care to reduce this sizable projected lifetime burden.

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美国大量商业保险人群先天性肺瓣膜疾病负担的回顾性分析

背景：患有先天性肺瓣膜疾病（CPVD）的婴儿在出生后的第一年就面临着终生的疾病负担和巨大的医疗费用。目的：评估CPVD患者从出生到65岁的护理成本和负担。方法：回顾性研究2006年1月1日至2024年4月30日期间，使用行政理赔数据对诊断为CPVD且理赔≥2次的商业保险患者的医疗费用和使用情况进行调查；最早的CPVD索赔定义索引日期。每位患者每年的费用按年龄类别计算。每个年龄组的平均年费用乘以年龄组持续时间，以估计整个年龄组期间的费用。每个年龄阶段的费用加起来估计到65岁的终生费用。对从出生到60个月和120个月连续符合条件的亚组进行敏感性分析。结果：在符合条件的患者（N = 22 751）中，53.2%的患者在第一年平均经历了1.8次与cpvd相关的住院：平均（标准差）累计住院天数为50.2 (74.2)；267 945 (737 565; m e d我n, 6487 (i n t e问u r t i l e r n g e(我问r), 0 - 238 486] i n s s o c i t e d c o s t s。m o n g t h o s e w我t h n p t e n t d m i f s s i o n o r l C p V d - r e t e d p C r o e d u r e s d u r i C n g h我l d h o o d, e V e r g n n u l C o s t s r n g e d f r o m 97 791 (288 606; 32 029 984 - 72 (762) 514 395 (222 926 572; 373 (114 107 - 530 671) y g b e C t e g o r y。5个月（n = 174） 28 893(69 019; 2852[400 ~ 23 858])， 1个月（n = 174） 1个月(59 537(111 982;13 690[918 ~ 66 625])，1个月（n = 174） 1个月(28 893（69 019;2852[400 ~ 23 858]）。在他21岁的时候，他的收入超过了100万美元，他的收入超过了100万美元，他的收入超过了100万美元，他的收入超过了100万美元，他的收入超过了100万美元。超过一半的患者在第一年住院近2个月，住院费用很高。经济负担和需要的护理很早就开始并保持稳定，反映了CPVD的慢性性质。结论：本研究证明了CPVD患者的疾病负担和持续医疗需求的终生镶嵌，以及早期生活护理的发展潜力，以减少这一巨大的预计终身负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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