Updates in pediatric kidney transplantation.

IF 2.5 4区医学 Q3 TRANSPLANTATION

Current Opinion in Organ Transplantation Pub Date : 2026-06-01 Epub Date: 2026-03-20 DOI:10.1097/MOT.0000000000001281

Rachel M Engen

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引用次数: 0

Abstract

Purpose of review: This manuscript highlights key areas of recent pediatric nephrology research that may be relevant to clinical practice.

Recent findings: Recent reviews of registry data have emphasized the long-term harms of even limited dialysis exposure in children, while studies of 'nonideal' donor kidneys in children have shown positive outcomes. New observational research suggests a benefit to thromboprophylaxis and aggressive fluid management immediately posttransplant, though the best prescriptions remain unclear. Belatacept and letermovir are emerging options for immunosuppression and CMV prophylaxis, respectively, that may have fewer side effects compared to standard of care; interventional studies of these drugs are ongoing.

Conclusion: Transplant teams should consider using a broader range of donor organs in select pediatric patients. Further interventional research on peritransplant thromboprophylaxis and fluid management is needed to optimize management strategies. The completion of ongoing belatacept and letermovir trials have the potential to substantially alter posttransplant standards of care.

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儿童肾移植的最新进展。

综述的目的：这篇文章强调了最近可能与临床实践相关的儿科肾脏病研究的关键领域。最近的发现：最近对登记数据的回顾强调了即使是有限的透析暴露对儿童的长期危害，而对儿童“非理想”供体肾脏的研究显示了积极的结果。新的观察性研究表明，在移植后立即进行血栓预防和积极的液体管理是有益的，尽管最佳处方仍不清楚。Belatacept和letermovir分别是免疫抑制和巨细胞病毒预防的新选择，与标准治疗相比，它们的副作用可能更少；这些药物的介入性研究正在进行中。结论：在选择儿科患者时，移植团队应考虑使用更广泛的供体器官。需要进一步对移植周围血栓预防和输液管理进行介入研究，以优化管理策略。正在进行的belataccept和letermovir试验的完成有可能大大改变移植后的护理标准。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Organ Transplantation 医学-移植

CiteScore

4.10

自引率

4.50%

发文量

124

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.