Rheumatic diseases in childhood: Clinical and immunological characteristics of a pediatric cohort at a tertiary hospital

Reumatologia clinica Pub Date : 2026-03-01 Epub Date: 2026-03-18 DOI:10.1016/j.reumae.2026.502076

Yedra Usón-Rodríguez , Giuliano Boselli-Oporto , Ignacio Ruiz del Olmo-Izuzquiza , Julia Ulier-Bellmunt , Marta Medrano-San Ildelfonso

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Abstract

Objective

To describe the clinical, immunological, and healthcare characteristics of patients attended in a Pediatric Rheumatology unit of a tertiary Spanish hospital over ten years.

Methods

Retrospective observational study including all patients under 18 years evaluated between 2014 and 2024. Demographic data, diagnoses, immunological profile, presence of uveitis, treatments, and final healthcare status were collected.

Results

A total of 925 patients were evaluated; 59.8% were female. The most prevalent disease in the clinic was JIA (29.4%), with oligoarticular JIA being the most frequent subtype (49.2%), of whom 71.5% were positive for ANA and 17.7% had uveitis. Autoinflammatory diseases accounted for 10.2% and connective tissue diseases for 7.4%. At the time of analysis, 45.3% were still followed in paediatric care, and 9% were in transition to adult consultations.

Conclusions

Our case series is similar to that described in other Pediatric Rheumatology units in our region, highlighting the higher frequency of oligoarticular JIA and its association with positive ANA.

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儿童风湿病：三级医院儿童队列的临床和免疫学特征

目的：描述十年来在西班牙三级医院儿科风湿病科就诊的患者的临床、免疫学和保健特点。方法：回顾性观察研究纳入2014 - 2024年所有18岁以下患者。收集了患者的人口统计数据、诊断、免疫特征、葡萄膜炎的存在、治疗和最终的医疗状况。结果：共评估925例患者；59.8%为女性。临床上最常见的疾病是JIA(29.4%)，其中以少关节型JIA最常见（49.2%），其中71.5%为ANA阳性，17.7%为葡萄膜炎。自身炎症性疾病占10.2%，结缔组织疾病占7.4%。在分析时，45.3%的人仍然接受儿科护理，9%的人正在过渡到成人咨询。结论：我们的病例系列与本地区其他儿科风湿病单位的病例系列相似，突出了低关节JIA的较高频率及其与ANA阳性的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Reumatologia clinica

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