N V Markov, N A Khodorik, M M Ilkovich, L N Novikova, I D Rabik, E V Privalova, N T Panina, A N Kulikov
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Abstract
Aim: To analyze the features of indicators of the external respiration function and their dynamics in patients with a combined pulmonary fibrosis and emphysema (CPFE).
Materials and methods: The results of studies of 44 patients with a confirmed diagnosis of CPFE are presented. As a control group, the results of a study of respiratory function of 41 patients with idiopathic pulmonary fibrosis (IPF) were analyzed. The study of respiratory function included the measurement of static lung volumes and capacities, speed indicators, airway response to inhalation of a bronchodilator drug, diffusive capacity of the lungs and gas exchange parameters.
Results: Spirometry indicators, such as vital capacity (p = 0.003), forced vital capacity - FVC (p = 0.003), forced expiratory volume in the first second - FEV1 (p = 0.02), were significantly higher in CPFE. The same differences were observed in the group of patients with severe dyspnea (p = 0.029, p = 0.019, p = 0.032, respectively). The FEV1/FVC ratio in CPFE was significantly lower (p = 0.013). The study of lung volumes and capacities by body plethysmography reveals higher values of total lung capacity (p = 0.002) and functional residual capacity of the lungs (p = 0.01) in CPFE. Alveolar volume was higher in CPFE (p = 0.046) and the DLCO/VA ratio was higher in IPF (p = 0.013). Diffusion capacity of the lungs was equally low in the group of patients with severe dyspnea and correlated with the severity of dyspnea. There were no statistically significant differences between the rate of decrease in FVC, DLCO, and other parameters.
Conclusion: In CPFE, the results of spirometry and bodyplethysmography do not reflect the degree of functional impairment and may make it difficult to assess the severity of the disease. Measurement of the diffusing capacity of the lungs and its components is an important method for determining the severity of functional disorders in patients with CPFE.
期刊介绍：
Терапевтический архив
The journal was founded by the prominent Russian therapists M.P. Konchalovsky and G.F. Lang in 1923. Then its editors-in-chief were Professors V.N. Vinogradov and A.G. Gukasyan. Since 1972, E.I. Chazov, Academician of the Russian Academy of Sciences, has been heading the editorial board of the journal.
Over 90 years, there have been more than 1000 issues where the authors and editorial staff have done their best for readers to keep abreast of current advances in medical science and practice and for physicians to master the advanced principles of recognition and treatment of a wide spectrum of visceral diseases.
The papers published in the journal (editorials, original articles, lectures, reviews, etc.) cover both current scientific achievements and practical experience in diagnosing, treating, and preventing visceral diseases. The authors of publications are not only Russian, but also foreign scientists and physicians. All papers are peer-reviewed by highly qualified Russian specialists.
The journal is published monthly. Traditionally, each issue has predominantly certain thematic areas covering individual therapy specializations. Every year, one of the issues is devoted to related problems in practical medicine (allergology and immunology, neurology and psychiatry, obstetrics, oncology, etc.). This all draws the attention of the reading public to the journal.
The journal is indexed in RSCI (Russian Science Citation Index), PubMed/Medline, Index Medicus, Scopus/EMBASE, Web of Science Core Collection (Science Citation Index Expanded), Web of Science (Russian Science Citation Index - RSCI, Current Contents Connect, BIOSIS Previews), Google Scholar, Ulrich''s Periodicals Directory.
The journal is included in the list of periodicals recommended by the Higher Attestation Committee for publishing the papers containing the basic materials of doctoral and candidate dissertations.
By the decision of the Presidium of the Russian Academy of Medical Sciences, the “Therapevticheskiy Arkhiv” was awarded the Botkin medal. It was admitted to the European Association of Sciences Editors (EASE).
The journal was honored with the Golden Press Fund decoration at the 13th International Press Professional Exhibition.
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