Factors Associated with Symptomatic Dermographism: Findings from the UCARE PREVALENCE-D Study

IF 11.4 1区医学 Q1 DERMATOLOGY

American Journal of Clinical Dermatology Pub Date : 2026-03-17 DOI:10.1007/s40257-026-01015-4

Kanokvalai Kulthanan, Jonathan A. Bernstein, Michael Rudenko, Pascale Salameh, Chulaluk Komoltri, Zainab Abdul Hameed, Esra Adışen, Salma Al Abri, Mona Al-Ahmad, Bushra Al Hinai, Anastasiia Allenova, Saad Alshareef, Nattha Angkoolpakdeekul, Rand Arnaout, Joanna Bartosińska, Ivan Cherrez-Ojeda, Leena Chularojanamontri, Paulo Ricardo Criado, Heyam Elsaeed, Roberta Fachini Jardim Criado, Ahmed Farahat, Cesar Alberto Galvan Calle, Ana Maria Giménez-Arnau, Kiran Godse, Maia Gotua, Mehmet Gülengül, Michihiro Hide, Naoko Inomata, Chang-Gyu Jung, Alicja Kasperska-Zając, Maryam Khoshkhui, Pavel Kolkhir, Dorota Krasowska, Jomgriditip Laomoleethorn, Antonina Maiorowa, Prynn Manuskiatti, Raisa Meshkova, Dragan Mijakoski, Melba Muñoz, Iman Nasr, Denise Neiva Santos de Aquino Arnoldi, Rabia Öztaş Kara, Teerapat Paringkarn, Juliette Pérez-Manich, Indrashis Podder, Karla Robles-Velasco, Isabel Rosmaninho, Phuwakorn Saengthong-aram, Giorgi Shengelidze, Sariya Sittiwanaruk, Rana Tafrishi, Natasa Teovska Mitrevska, Vesna Trajkova, Papapit Tuchinda, Noldtawat Viriyaskultorn, Teerapat Wannawittayapa, Pornjira Wattanasillawat, Anushka Wilson, Young-Min Ye, Anna Zalewska-Janowska, Marcus Maurer, Torsten Zuberbier

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引用次数: 0

Abstract

Background and Objective

Symptomatic dermographism (SD), the most common chronic inducible urticaria subtype, manifests as strip-shaped, pruritic wheals after skin friction. Conclusive data on its associated factors are limited, and direct comparisons between individuals with and without SD remain scarce. We aimed to identify factors associated with SD internationally.

Methods

The PREVALENCE-D (Prevalence Estimation of Dermographism) study was an international cross-sectional survey conducted from 2021 to 2024 across 19 countries. An expert-designed questionnaire diagnosed SD and assessed potential associated factors. SD participants were defined as those who self-reported chronic recurrent urticarial dermographism with itch. Factors associated with SD were identified by comparing participants with and without SD.

Results

Of 68,513 participants, 3101 had SD (female 73.3%). Their mean age was 40.2 ± 16.2 years. Key factors associated with SD included atopic dermatitis (adjusted odds ratio [aOR] 4.20, 95% confidence interval [CI] 3.62‒4.88) and allergic rhinitis (aOR 2.11, 95% CI 1.88‒2.37). Participants with at least one atopic condition (allergic rhinitis, atopic dermatitis, or asthma) were significantly more likely to have SD (aOR 2.70, 95% CI 2.47‒2.95). Those with all three atopic conditions had a further increased likelihood of SD (aOR 7.75, 95% CI 5.31‒11.29). Other associations included working and older age groups, female sex, dyslipidemia, and thyroid disease.

Conclusions

Atopic dermatitis and allergic rhinitis emerged as the strongest correlates of SD, especially those with all three atopic conditions. Thus, allergic comorbidities should be assessed in SD patients. Further research is needed to clarify the pathophysiological relationship between these conditions and SD. [Graphical abstract available online]

Graphical Abstract

The alternative text for this image may have been generated using AI.

查看原文本刊更多论文

与症状性皮肤统计学相关的因素：来自UCARE患病率- d研究的发现。

背景与目的：症状性皮肤特征（SD）是最常见的慢性诱导性荨麻疹亚型，表现为皮肤摩擦后出现的条状瘙痒性皮疹。有关其相关因素的结论性数据有限，并且在患有和不患有SD的个体之间的直接比较仍然很少。我们的目的是在国际上确定与SD相关的因素。方法：患病率- d（人口统计学患病率估计）研究是一项国际横断面调查，于2021年至2024年在19个国家进行。专家设计的问卷诊断了SD并评估了潜在的相关因素。SD参与者被定义为那些自我报告慢性复发性荨麻疹伴瘙痒的人群。通过比较有和没有SD的参与者来确定与SD相关的因素。结果：68,513名参与者中，3101名患有SD（女性73.3%）。平均年龄40.2±16.2岁。与SD相关的关键因素包括特应性皮炎（调整比值比[aOR] 4.20, 95%可信区间[CI] 3.62-4.88）和变应性鼻炎（调整比值比[aOR] 2.11, 95%可信区间[CI] 1.88-2.37）。至少有一种特应性疾病（变应性鼻炎、特应性皮炎或哮喘）的参与者更有可能发生SD （aOR 2.70, 95% CI 2.47-2.95）。同时患有三种特应性疾病的患者发生SD的可能性进一步增加（aOR 7.75, 95% CI 5.31-11.29）。其他相关因素包括工作和老年群体、女性、血脂异常和甲状腺疾病。结论：特应性皮炎和变应性鼻炎是SD最强的相关因素，尤其是同时存在三种特应性条件的患者。因此，应评估SD患者的过敏性合并症。这些疾病与SD之间的病理生理关系有待进一步研究。[在线提供图形摘要]。

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来源期刊

American Journal of Clinical Dermatology 医学-皮肤病学

CiteScore

15.20

自引率

2.70%

发文量

审稿时长

>12 weeks

期刊介绍： The American Journal of Clinical Dermatology is dedicated to evidence-based therapy and effective patient management in dermatology. It publishes critical review articles and clinically focused original research covering comprehensive aspects of dermatological conditions. The journal enhances visibility and educational value through features like Key Points summaries, plain language summaries, and various digital elements, ensuring accessibility and depth for a diverse readership.