Nanoplastics at the Placenta–Fetal Interface: Emerging Chemical Toxicology Concerns

IF 4.1 3区医学 Q2 CHEMISTRY, MEDICINAL

Chemical Research in Toxicology Pub Date : 2026-07-20 Epub Date: 2026-03-18 DOI:10.1021/acs.chemrestox.6c00015

Rasin Puthiyavalappil*, Praveena Prabhakaran and Jebiti Haribabu,

引用次数: 0

Abstract

The interaction of nanoplastics with trophoblasts can potentially disrupt fetal development. The additives associated with nanoplastics, their surface chemistry, and protein corona may lead to oxidative stress and affect the cellular functions. Detailed studies revealing a clear mechanism using an advanced placental model is essential to assess developmental toxicity and guide risk assessment.

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纳米塑料在胎盘-胎儿界面：新兴的化学毒理学问题。

纳米塑料与滋养细胞的相互作用可能潜在地破坏胎儿发育。与纳米塑料相关的添加剂及其表面化学和蛋白质电晕可能导致氧化应激并影响细胞功能。利用先进的胎盘模型进行详细的研究，揭示其明确的机制，对于评估发育毒性和指导风险评估至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Research in Toxicology 医学-毒理学

CiteScore

7.90

自引率

7.30%

发文量

215

审稿时长

3.5 months

期刊介绍： Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.