The Relationship Between Polycystic Ovary Syndrome (PCOS) and Depression

IF 2.8 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Clinical Endocrinology Pub Date : 2026-07-02 Epub Date: 2026-03-15 DOI:10.1111/cen.70124

Asimina I. Karampela, Maralyn Druce

{"title":"The Relationship Between Polycystic Ovary Syndrome (PCOS) and Depression","authors":"Asimina I. Karampela, Maralyn Druce","doi":"10.1111/cen.70124","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder, frequently accompanied by psychological comorbidities including depression. The aim of this narrative review is to summarise the latest research regarding potential contributors to and underpinning mechanisms of this relationship.</p>\n </section>\n \n <section>\n \n <h3> Design</h3>\n \n <p>A detailed search of the PubMed database was carried out beginning with systematic reviews and using the ‘snowballing’ method to identify further studies. The results yielded were assessed for quality using the GRADE framework. Depression in all studies was assessed using validated questionnaires.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The association of PCOS and depression is bidirectional and multifactorial. The role of biological factors such as hyperandrogenism, metabolic dysregulation, chronic low-grade inflammation, gut microbiome, and genetic and epigenetic factors are highlighted. Also, psychosocial contributors includingillness perception (obesity, acne and hirsutism), menstruation, infertility issues, and sexual dysfunction, as well as eating disorders have a prevalent role. The majority of the studies included were systematic reviews and cross-sectional original research studies.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Given the complex pathophysiology underpinning both diseases independently as well as in combination, despite evolving research, there is no single unifying link. However, this highlights the need for mental health risk stratification, addressing possible contributing factors, and offering the support required for patients with PCOS and depression.</p>\n </section>\n </div>","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":"105 2","pages":"131-140"},"PeriodicalIF":2.8000,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cen.70124","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Endocrinology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/cen.70124","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/3/15 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder, frequently accompanied by psychological comorbidities including depression. The aim of this narrative review is to summarise the latest research regarding potential contributors to and underpinning mechanisms of this relationship.

Design

A detailed search of the PubMed database was carried out beginning with systematic reviews and using the ‘snowballing’ method to identify further studies. The results yielded were assessed for quality using the GRADE framework. Depression in all studies was assessed using validated questionnaires.

Results

The association of PCOS and depression is bidirectional and multifactorial. The role of biological factors such as hyperandrogenism, metabolic dysregulation, chronic low-grade inflammation, gut microbiome, and genetic and epigenetic factors are highlighted. Also, psychosocial contributors includingillness perception (obesity, acne and hirsutism), menstruation, infertility issues, and sexual dysfunction, as well as eating disorders have a prevalent role. The majority of the studies included were systematic reviews and cross-sectional original research studies.

Conclusion

Given the complex pathophysiology underpinning both diseases independently as well as in combination, despite evolving research, there is no single unifying link. However, this highlights the need for mental health risk stratification, addressing possible contributing factors, and offering the support required for patients with PCOS and depression.

查看原文本刊更多论文

多囊卵巢综合征（PCOS）与抑郁症的关系。

目的：多囊卵巢综合征（PCOS）是一种常见的内分泌疾病，常伴有抑郁症等心理合并症。这篇叙述性综述的目的是总结关于这种关系的潜在贡献者和基础机制的最新研究。设计：对PubMed数据库进行了详细的搜索，从系统评价开始，并使用“滚雪球”方法确定进一步的研究。使用GRADE框架评估所得结果的质量。所有研究中的抑郁症均采用有效问卷进行评估。结果：PCOS与抑郁的关系是双向的、多因素的。生物因素如高雄激素、代谢失调、慢性低度炎症、肠道微生物组、遗传和表观遗传因素的作用被强调。此外，心理社会因素包括疾病认知（肥胖、痤疮和多毛症）、月经、不孕问题、性功能障碍以及饮食失调也有普遍的作用。纳入的大多数研究是系统综述和横断面原始研究。结论：考虑到这两种疾病的复杂病理生理学，尽管研究不断发展，但没有单一的统一联系。然而，这突出了心理健康风险分层的必要性，解决可能的影响因素，并为多囊卵巢综合征和抑郁症患者提供所需的支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Endocrinology 医学-内分泌学与代谢

CiteScore

6.40

自引率

3.10%

发文量

192

审稿时长

1 months

期刊介绍： Clinical Endocrinology publishes papers and reviews which focus on the clinical aspects of endocrinology, including the clinical application of molecular endocrinology. It does not publish papers relating directly to diabetes care and clinical management. It features reviews, original papers, commentaries, correspondence and Clinical Questions. Clinical Endocrinology is essential reading not only for those engaged in endocrinological research but also for those involved primarily in clinical practice.