{"title":"Acetyl-L-Carnitine in the Treatment of Peripheral Neuropathies: A Narrative Review.","authors":"Diego Maria Michele Fornasari","doi":"10.1007/s40122-026-00826-x","DOIUrl":null,"url":null,"abstract":"<p><p>Acetyl-L-carnitine is an ester of L-carnitine, both endogenous molecules, with a vital role in lipid metabolism. Exogenously delivered acetyl-L-carnitine is endowed with neuroprotective and neurotrophic actions due to its antioxidant and metabolic properties. Moreover, acetyl-L-carnitine is an epigenetic regulator of genes involved in analgesia such as the metabotropic glutamate 2 receptor in the presynaptic neurons and of neurotrophic factors including nerve growth factor. Accordingly, its long-term neurotrophic and analgesic activity has been confirmed in animal models of chronic inflammatory and neuropathic pain and in clinical studies in patients with peripheral neuropathies. The aim of this narrative review was to summarise the available evidence on the usefulness of acetyl-L-carnitine in the treatment of peripheral neuropathies.</p>","PeriodicalId":19908,"journal":{"name":"Pain and Therapy","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pain and Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s40122-026-00826-x","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Acetyl-L-carnitine is an ester of L-carnitine, both endogenous molecules, with a vital role in lipid metabolism. Exogenously delivered acetyl-L-carnitine is endowed with neuroprotective and neurotrophic actions due to its antioxidant and metabolic properties. Moreover, acetyl-L-carnitine is an epigenetic regulator of genes involved in analgesia such as the metabotropic glutamate 2 receptor in the presynaptic neurons and of neurotrophic factors including nerve growth factor. Accordingly, its long-term neurotrophic and analgesic activity has been confirmed in animal models of chronic inflammatory and neuropathic pain and in clinical studies in patients with peripheral neuropathies. The aim of this narrative review was to summarise the available evidence on the usefulness of acetyl-L-carnitine in the treatment of peripheral neuropathies.
期刊介绍：
Pain and Therapy is an international, open access, peer-reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of pain therapies and pain-related devices. Studies relating to diagnosis, pharmacoeconomics, public health, quality of life, and patient care, management, and education are also encouraged.
Areas of focus include, but are not limited to, acute pain, cancer pain, chronic pain, headache and migraine, neuropathic pain, opioids, palliative care and pain ethics, peri- and post-operative pain as well as rheumatic pain and fibromyalgia.
The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports, trial protocols, short communications such as commentaries and editorials, and letters. The journal is read by a global audience and receives submissions from around the world. Pain and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.
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