Ziwei Lu, Chengcheng Zhao, Tong Zhi, Huadong Ni, Ming Yao
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引用次数: 0
Abstract
Introduction: Insulin resistance (IR) is an important factor in the development of chronic pain. The triglyceride-glucose (TyG) index is a convenient measure of insulin resistance. However, as a common subtype of chronic pain, the relationship between postherpetic neuralgia (PHN) and the TyG index remains unclear. Through a retrospective analysis of the relationship between the TyG index and the incidence of PHN, we aim to determine whether the TyG index possesses predictive capability for PHN occurrence, thereby enabling the development of strategies to reduce the incidence of PHN.
Methods: This retrospective study analyzed the medical records of patients diagnosed with acute herpes zoster (with a disease course of ≤ 1 month) in the Pain Department of Jiaxing University Affiliated Hospital from November 2024 to May 2025. Eligible patients were those who had available data on triglycerides and glucose, and no history of diabetes. Relevant clinical data were extracted from existing records and subjected to retrospective analysis. The numerical rating scale (NRS) score was utilized as the primary outcome measure to assess whether patients developed PHN. Those who still had pain (NRS ≥ 4) were classified as the PHN group, while those without pain symptoms (NRS < 4) were classified as the non-PHN group. The association between the TyG index and PHN was evaluated using multi-model logistic regression. In addition, the nonlinear relationship between these indicators and the results was studied using a restricted cubic spline plot. Subsequently, subgroup analyses were conducted on the sensitive population. The predictive value of the TyG index for PHN was evaluated using the receiver operating characteristic curve.
Results: The retrospective study comprised 157 patients with acute herpes zoster, of whom 55 were male and 102 female, with a mean age of 64.87 ± 11.67 years. The TyG index in patients with acute herpes zoster exhibited a nonlinear relationship with PHN, with an odds ratio (OR) and 95% confidence interval (CI) of 4.32 (1.56-11.97). A linear correlation was found between the triglyceride-glucose-body mass index (TyG-BMI) and PHN, with OR and 95% CI of 1.07 (1.02-1.11). The TyG index and the TyG-BMI showed similar performance on the receiver operating characteristic (ROC) curve for evaluating PHN and have certain predictive value.
Conclusion: Higher TyG index and TyG-BMI are associated with an increased risk of PHN.
期刊介绍：
Pain and Therapy is an international, open access, peer-reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of pain therapies and pain-related devices. Studies relating to diagnosis, pharmacoeconomics, public health, quality of life, and patient care, management, and education are also encouraged.
Areas of focus include, but are not limited to, acute pain, cancer pain, chronic pain, headache and migraine, neuropathic pain, opioids, palliative care and pain ethics, peri- and post-operative pain as well as rheumatic pain and fibromyalgia.
The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports, trial protocols, short communications such as commentaries and editorials, and letters. The journal is read by a global audience and receives submissions from around the world. Pain and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.
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