Treatment-refractory giardiasis is predominantly an imported infection from South Asia associated with Giardia sub-assemblage BIII: a five-year study from the Czech Republic

IF 3.3 2区医学 Q1 PARASITOLOGY

International journal for parasitology Pub Date : 2026-08-01 Epub Date: 2026-03-11 DOI:10.1016/j.ijpara.2026.104821

Aneta Perglerová, Ivana Zicklerová, František Stejskal, Filip Weisz, Milan Trojánek, Magdalena Uzlíková, Eva Nohýnková, Pavla Tůmová

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Abstract

Giardiasis is a cosmopolitan parasitic infection caused by a protozoan pathogen Giardia intestinalis. A high number of failures complicates the metronidazole (MTZ) treatment. However, long-term studies characterising the parasites associated with MTZ treatment failures are lacking. This study was designed to map Giardia genotypes, clinical manifestations and geographical origin of giardiasis in a patient cohort from the Czech Republic. A multilocus genotyping was applied to 93 Giardia DNA isolates collected over five years in a tertiary care hospital diagnostic facility, and corresponding patient data, including the treatment outcomes, were evaluated. We found that treatment-refractory giardiasis (32.9% of infections) was always symptomatic, associated with South Asian origin and caused mainly by sub-assemblage BIII parasites. This study confirms the limited efficacy of MTZ treatment, especially in travellers returning from South Asia.

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难治性贾第虫病主要是一种来自南亚的输入性感染，与贾第虫亚组合BIII有关：捷克共和国的一项为期五年的研究。

贾第虫病是由原生动物病原体肠贾第虫引起的世界性寄生虫感染。大量的失败使甲硝唑（MTZ）治疗复杂化。然而，对与MTZ治疗失败相关的寄生虫特征的长期研究是缺乏的。本研究旨在绘制捷克共和国患者队列中贾第鞭毛虫病的基因型、临床表现和地理起源。对一家三级保健医院诊断机构5年来收集的93株贾第鞭毛虫DNA分离株进行了多位点基因分型，并对相应的患者数据（包括治疗结果）进行了评估。我们发现难治性贾第虫病（32.9%的感染）总是有症状，与南亚起源有关，主要由亚组合BIII寄生虫引起。这项研究证实了MTZ治疗的有限疗效，特别是对从南亚返回的旅行者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal for parasitology 医学-寄生虫学

CiteScore

8.40

自引率

2.50%

发文量

审稿时长

23 days

期刊介绍： International Journal for Parasitology offers authors the option to sponsor nonsubscriber access to their articles on Elsevier electronic publishing platforms. For more information please view our Sponsored Articles page. The International Journal for Parasitology publishes the results of original research in all aspects of basic and applied parasitology, including all the fields covered by its Specialist Editors, and ranging from parasites and host-parasite relationships of intrinsic biological interest to those of social and economic importance in human and veterinary medicine and agriculture.