{"title":"Folic Acid-Conjugated Nanocarriers for Targeted Cancer Therapy: Recent Patents and Future Prospects.","authors":"Nandini Sharma, Yukta Garg, Raj Kumar Narang, Amandeep Singh","doi":"10.2174/0115665232425332251126045318","DOIUrl":null,"url":null,"abstract":"<p><p>As folate receptors are overexpressed on the surface of many tumor cells, folic acidconjugated nanocarriers have emerged as a promising approach for targeted cancer therapy. These nanocarriers enhance therapeutic efficacy while reducing systemic toxicity and adverse effects by enabling selective drug delivery. The design, synthesis, and application of folic acid-functionalized nanocarriers such as polymeric nanoparticles, liposomes, dendrimers, and micelles have advanced significantly, as evidenced by recent patents. Key objectives of these developments include improving stability, drug loading capacity, controlled release, and receptor-mediated endocytosis. To translate these targeted nanocarriers from bench to bedside, this study examines significant patents submitted over the past ten years, evaluates their clinical potential, and discusses current challenges and potential future directions.</p>","PeriodicalId":10798,"journal":{"name":"Current gene therapy","volume":" ","pages":""},"PeriodicalIF":4.1000,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current gene therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115665232425332251126045318","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
Abstract
As folate receptors are overexpressed on the surface of many tumor cells, folic acidconjugated nanocarriers have emerged as a promising approach for targeted cancer therapy. These nanocarriers enhance therapeutic efficacy while reducing systemic toxicity and adverse effects by enabling selective drug delivery. The design, synthesis, and application of folic acid-functionalized nanocarriers such as polymeric nanoparticles, liposomes, dendrimers, and micelles have advanced significantly, as evidenced by recent patents. Key objectives of these developments include improving stability, drug loading capacity, controlled release, and receptor-mediated endocytosis. To translate these targeted nanocarriers from bench to bedside, this study examines significant patents submitted over the past ten years, evaluates their clinical potential, and discusses current challenges and potential future directions.
期刊介绍：
Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of diseases. Cell therapy manuscripts can also include application in diseases when cells have been genetically modified. Current Gene Therapy publishes full-length/mini reviews and original research on the latest developments in gene transfer and gene expression analysis, vector development, cellular genetic engineering, animal models and human clinical applications of gene and cell therapy for the treatment of diseases.
Current Gene Therapy publishes reviews and original research containing experimental data on gene and cell therapy. The journal also includes manuscripts on technological advances, ethical and regulatory considerations of gene and cell therapy. Reviews should provide the reader with a comprehensive assessment of any area of experimental biology applied to molecular medicine that is not only of significance within a particular field of gene therapy and cell therapy but also of interest to investigators in other fields. Authors are encouraged to provide their own assessment and vision for future advances. Reviews are also welcome on late breaking discoveries on which substantial literature has not yet been amassed. Such reviews provide a forum for sharply focused topics of recent experimental investigations in gene therapy primarily to make these results accessible to both clinical and basic researchers. Manuscripts containing experimental data should be original data, not previously published.
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