Revolutionizing Drug and Gene Delivery: Cutting-Edge Smart Polymers for Precision Release.

IF 4.1 4区医学 Q2 GENETICS & HEREDITY

Current gene therapy Pub Date : 2026-03-03 DOI:10.2174/0115665232390238251121074917

Atul Pratap Singh, Shamim, Dhananjay Taumar, Himanchal Sharma, Anshu Gujjar, Vatan Chaudhary, Iram Rajpoot

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引用次数: 0

Abstract

Smart polymer-based drug and gene delivery systems are revolutionizing contemporary therapeutics with their increased specificity, efficacy, and safety. Compared to traditional carriers, smart polymers exhibit stimuli-responsive behavior, enabling controlled and site-specific drug release in response to physiological cues, such as pH, temperature, or enzyme activity. Such dynamic materials allow accurate drug delivery and minimize systemic toxicity, along with providing improved bioavailability. This review delves into some of the latest developments in stimuliresponsive polymers, nanoplatforms with multiple functions, and hybrid polymer systems, highlighting their potential in controlled drug delivery and theragnostics. Challenges, including biocompatibility, stability, and overcoming biological barriers, such as the blood-brain barrier, are also covered. By combining smart polymers with nanotechnology and targeted personalized medicine strategies, the discipline is set to redefine targeted therapy and maximize therapeutic outcomes.

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革命性的药物和基因传递：精密释放的尖端智能聚合物。

基于智能聚合物的药物和基因传递系统以其更高的特异性、有效性和安全性正在彻底改变当代治疗方法。与传统载体相比，智能聚合物表现出刺激响应行为，能够根据生理线索（如pH值、温度或酶活性）控制和特定位点的药物释放。这种动态材料可以准确地给药，最大限度地减少全身毒性，同时提供更好的生物利用度。本文综述了刺激反应聚合物、多功能纳米平台和混合聚合物系统的最新进展，强调了它们在控制药物传递和治疗方面的潜力。挑战，包括生物相容性，稳定性和克服生物屏障，如血脑屏障，也包括在内。通过将智能聚合物与纳米技术和针对性个性化医疗策略相结合，该学科将重新定义靶向治疗并最大化治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current gene therapy 医学-遗传学

CiteScore

6.70

自引率

2.80%

发文量

期刊介绍： Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of diseases. Cell therapy manuscripts can also include application in diseases when cells have been genetically modified. Current Gene Therapy publishes full-length/mini reviews and original research on the latest developments in gene transfer and gene expression analysis, vector development, cellular genetic engineering, animal models and human clinical applications of gene and cell therapy for the treatment of diseases. Current Gene Therapy publishes reviews and original research containing experimental data on gene and cell therapy. The journal also includes manuscripts on technological advances, ethical and regulatory considerations of gene and cell therapy. Reviews should provide the reader with a comprehensive assessment of any area of experimental biology applied to molecular medicine that is not only of significance within a particular field of gene therapy and cell therapy but also of interest to investigators in other fields. Authors are encouraged to provide their own assessment and vision for future advances. Reviews are also welcome on late breaking discoveries on which substantial literature has not yet been amassed. Such reviews provide a forum for sharply focused topics of recent experimental investigations in gene therapy primarily to make these results accessible to both clinical and basic researchers. Manuscripts containing experimental data should be original data, not previously published.