{"title":"Mechanisms of Action and Biomarker Potential of ncRNAs in Hepatocellular Carcinoma and Liver Fibrosis: A Review.","authors":"Eun Jung Sohn, Sae-Ock Oh","doi":"10.1155/ancp/2283163","DOIUrl":null,"url":null,"abstract":"<p><p>Liver diseases constitute a major global health burden, contributing substantially to morbidity and mortality worldwide. Although effective therapeutic strategies have been developed for key risk factors, such as hepatitis C infection, therapeutic options for most other liver diseases remain limited. Noncoding RNAs (ncRNAs), which regulate diverse cellular and molecular processes, have emerged as promising therapeutic targets and biomarkers in liver diseases. In this study, we summarize the mechanisms of action and functional roles of ncRNAs, such as long ncRNAs (lncRNAs), circular RNAs (circRNAs), and PIWI-interacting RNAs (piRNAs), to improve therapeutic strategies and diagnostic precision in liver diseases, such as liver fibrosis and hepatocellular carcinoma (HCC).</p>","PeriodicalId":49326,"journal":{"name":"Analytical Cellular Pathology","volume":"2026 1","pages":"e2283163"},"PeriodicalIF":2.5000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580803/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical Cellular Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/ancp/2283163","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Liver diseases constitute a major global health burden, contributing substantially to morbidity and mortality worldwide. Although effective therapeutic strategies have been developed for key risk factors, such as hepatitis C infection, therapeutic options for most other liver diseases remain limited. Noncoding RNAs (ncRNAs), which regulate diverse cellular and molecular processes, have emerged as promising therapeutic targets and biomarkers in liver diseases. In this study, we summarize the mechanisms of action and functional roles of ncRNAs, such as long ncRNAs (lncRNAs), circular RNAs (circRNAs), and PIWI-interacting RNAs (piRNAs), to improve therapeutic strategies and diagnostic precision in liver diseases, such as liver fibrosis and hepatocellular carcinoma (HCC).
期刊介绍：
Analytical Cellular Pathology is a peer-reviewed, Open Access journal that provides a forum for scientists, medical practitioners and pathologists working in the area of cellular pathology. The journal publishes original research articles, review articles, and clinical studies related to cytology, carcinogenesis, cell receptors, biomarkers, diagnostic pathology, immunopathology, and hematology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
