Emerging role of mitoNEET as mitochondrial sensor of hypoxia

IF 2.8 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Biological Inorganic Chemistry Pub Date : 2026-03-09 DOI:10.1007/s00775-026-02139-y

Nghi Thao Hoang, Kourosh Honarmand Ebrahimi

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引用次数: 0

Abstract

Mitochondria are organelles whose function and dynamics, that is fission, fusion, transport and selective removal (mitophagy), are fundamental for eukaryotic cells. Their dysfunction is associated with age-related neurodegeneration and the aging immune system. MitoNEET, an iron-sulfur (Fe-S) cluster-containing protein localised at the outer membrane of mitochondria, has emerged as a key regulator of mitochondrial respiration and linked to fission, fusion, and mitophagy. In this perspective article, we discuss recent emerging evidence describing the mitoNEET [2Fe-2S] cluster role as a sensor of the cellular level of O₂. These findings provide a mechanistic explanation of how mitochondria sense hypoxia, which affects their bioelectrochemistry and dynamics. We hope our data and analysis stimulate future research to fully understand the chemistry and biology of this intriguing Fe-S protein. These studies are expected to reveal new mechanistic insight into mitochondrial function and dynamics and help develop new therapeutics for inflammatory and age-related diseases.

AbstractSection Graphical Abstract

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mitoNEET作为线粒体缺氧传感器的新作用。

线粒体是一种细胞器，其功能和动力学，即裂变、融合、运输和选择性去除（线粒体自噬），是真核细胞的基础。它们的功能障碍与年龄相关的神经变性和老化的免疫系统有关。MitoNEET是一种位于线粒体外膜的含铁硫（Fe-S）簇的蛋白，是线粒体呼吸的关键调节因子，与分裂、融合和线粒体自噬有关。在这篇前瞻性文章中，我们讨论了最近出现的描述mitoNEET [2Fe-2S]簇作为细胞水平O2传感器作用的证据。这些发现提供了线粒体如何感知缺氧的机制解释，这影响了它们的生物电化学和动力学。我们希望我们的数据和分析能够刺激未来的研究，以充分了解这种有趣的Fe-S蛋白的化学和生物学。这些研究有望揭示线粒体功能和动力学的新机制，并有助于开发炎症和年龄相关疾病的新疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biological Inorganic Chemistry 化学-生化与分子生物学

CiteScore

5.90

自引率

3.30%

发文量

审稿时长

3 months

期刊介绍： Biological inorganic chemistry is a growing field of science that embraces the principles of biology and inorganic chemistry and impacts other fields ranging from medicine to the environment. JBIC (Journal of Biological Inorganic Chemistry) seeks to promote this field internationally. The Journal is primarily concerned with advances in understanding the role of metal ions within a biological matrix—be it a protein, DNA/RNA, or a cell, as well as appropriate model studies. Manuscripts describing high-quality original research on the above topics in English are invited for submission to this Journal. The Journal publishes original articles, minireviews, and commentaries on debated issues.