Study of the interaction of ferrocenium salts with oligonucleotide by CVA, UV-visible and CD-spectroscopy

IF 2.8 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Biological Inorganic Chemistry Pub Date : 2026-03-09 DOI:10.1007/s00775-026-02138-z

Ludmila N. Telegina, Anastasia S. Sipieva, Daria A. Utepova, Alexey N. Rodionov, Alexander A. Simenel

引用次数: 0

Abstract

The complexation of ferrocenium salts (with various anions) with an oligonucleotide (CCACGAGCTCCCACATGGT, OL) was studied using a combination of electrochemical (CVA) and spectral (UV-vis and CD spectroscopy) methods. It has been shown that varying the nature of the counteranion has virtually no effect on the binding constant to ferrocenium. However, the counterion can alter the secondary structure of the oligonucleotide, which may open a way to tune the biological activity of the ferrocenium cation.

查看原文本刊更多论文

二茂铁盐与寡核苷酸相互作用的CVA、uv -可见和cd光谱研究。

采用电化学（CVA）和光谱（紫外-可见光谱和CD光谱）相结合的方法，研究了二茂铁盐（含各种阴离子）与寡核苷酸（CCACGAGCTCCCACATGGT， OL）的络合作用。研究表明，改变反阴离子的性质对二茂铁的结合常数几乎没有影响。然而，反离子可以改变寡核苷酸的二级结构，这可能为调节二茂铁阳离子的生物活性开辟了一条途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Biological Inorganic Chemistry 化学-生化与分子生物学

CiteScore

5.90

自引率

3.30%

发文量

审稿时长

3 months

期刊介绍： Biological inorganic chemistry is a growing field of science that embraces the principles of biology and inorganic chemistry and impacts other fields ranging from medicine to the environment. JBIC (Journal of Biological Inorganic Chemistry) seeks to promote this field internationally. The Journal is primarily concerned with advances in understanding the role of metal ions within a biological matrix—be it a protein, DNA/RNA, or a cell, as well as appropriate model studies. Manuscripts describing high-quality original research on the above topics in English are invited for submission to this Journal. The Journal publishes original articles, minireviews, and commentaries on debated issues.