Functional cycling ergometry with or without electrical stimulation in individuals with secondary progressive multiple sclerosis: A randomized controlled trial

IF 3 3区医学 Q2 CLINICAL NEUROLOGY

Multiple sclerosis and related disorders Pub Date : 2026-05-01 Epub Date: 2026-02-24 DOI:10.1016/j.msard.2026.107095

Alexandra C. Simpson , Jennifer Keller , Thomas Shoemaker , Julie Fiol , Michael Comisac , Daniel Becker , Sandra D. Cassard , Kathleen Zackowski , Scott D. Newsome

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引用次数: 0

Abstract

Background

People with secondary progressive multiple sclerosis (PwSPMS) experience symptoms impacting their ability to walk or exercise. Functional electrical stimulation (FES) cycling is a promising, safe therapeutic intervention for MS, but relatively little is known about its use in PwSPMS with moderate to severe disability.

Objective

To determine effects of active FES and passive cycling on walking speed and other disability measures in PwSPMS.

Methods

PwSPMS and Expanded Disability Status Scale (EDSS) 5.0–7.0 were randomized to a 12-week FES-assisted or passive (control) cycling intervention. The primary outcome was change in Timed 25-Foot Walk (T25FW [s]) pre-post intervention. Secondary outcomes assessed functional mobility (Timed Up and Go [TUG], 2-Minute Walk Test), strength, disability, cognition and quality of life.

Results

Fourteen participants completed the intervention (8 active FES; 6 passive). One active FES cyclist with an unrelated injury was excluded from analysis. Mean ±SD age was 54.1 ± 8.9 years and 85 % were female. Participants tolerated the intervention. No significant differences were observed between participants receiving FES compared to passive cycling in any measures. Within groups, FES cyclists trended towards but did not reach significant improvement in T25FW (10.2 to 8.4 s; p = 0.08), while passive cyclists significantly improved in TUG (12.4 to 11.6 s; p = 0.03).

Conclusion

Change in ambulatory function did not differ in participants receiving FES versus passive cycling. Within-group improvement occurred in isolated measures and no adverse events occurred, demonstrating feasibility and acceptability. Longer interventions may be necessary to demonstrate improvements beyond lack of decline, given greater baseline disability in this population.

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继发性进展性多发性硬化症患者在有或没有电刺激的情况下的功能循环几何测量：一项随机对照试验

继发性进行性多发性硬化症（PwSPMS）患者会出现影响其行走或运动能力的症状。功能性电刺激（FES）循环是一种有前景的、安全的多发性硬化症治疗干预措施，但对其在中度至重度残疾的PwSPMS中的应用知之甚少。目的探讨主动FES和被动骑行对PwSPMS患者步行速度及其他残疾指标的影响。方法spwspms和扩展残疾状态量表（EDSS） 5.0-7.0随机分为fes辅助或被动（对照）循环干预组。主要终点是干预前25英尺步行时间（T25FW [s]）的改变。次要结果评估了功能活动能力（Timed Up and Go [TUG]， 2分钟步行测试）、力量、残疾、认知和生活质量。结果14名参与者完成干预，其中主动FES 8名，被动FES 6名。一名不相关损伤的活跃FES自行车运动员被排除在分析之外。平均±SD年龄为54.1±8.9岁，85%为女性。参与者能够忍受这种干预。与被动骑车相比，接受FES的参与者在任何方面都没有显著差异。各组内，FES骑行者T25FW有改善趋势，但未达到显著改善（10.2 ~ 8.4 s, p = 0.08），而被动骑行者TUG有显著改善（12.4 ~ 11.6 s, p = 0.03）。结论接受FES和被动循环的参与者的运动功能变化无差异。孤立措施组内改善发生，无不良事件发生，证明可行性和可接受性。鉴于这一人群的基线残疾程度较高，可能需要更长时间的干预措施来证明没有下降之外的改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Multiple sclerosis and related disorders CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

20.00%

发文量

814

审稿时长

66 days

期刊介绍： Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.