Rural targeted messaging, multiplex salivary measurement, and rural equity in SARS-CoV-2 antibody testing: Protocol overview of a SeroNet investigation

IF 1.5 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Contemporary Clinical Trials Communications Pub Date : 2026-04-01 Epub Date: 2026-03-09 DOI:10.1016/j.conctc.2026.101627

Leah Maschino , Kelly A. Hirko , Christopher D. Heaney , Douglas A. Granger , Steve W. Granger , Anurag Dawadi , Lindsey Rose , Monicia Summers , Nora Pisanic , Olivia Aspiras , Stefan M.M. Goetz , Todd Lucas

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引用次数: 0

Abstract

Background

Rural communities were disproportionately impacted by the COVID-19 pandemic. Current and future pandemic preparedness in rural areas could be aided by serological (antibody) testing. However, benefits to be gained from serosurveillance are challenged both by the accessibility of serological testing resources in hard-to-reach rural areas, and by likely hesitancy towards their use in many rural communities. Trials are needed to evaluate outreach and health communication strategies that can increase rural receptivity towards serosurveillance.

Methods

We conducted a two-arm randomized controlled trial that recruited N = 194 participants from rural northern Michigan. In a single online session lasting approximately 45 min, participants were randomly assigned to view either a general SARS-CoV-2 antibody testing didactic video, or a rural targeted didactic video co-created with a rural community advisory board and containing unique rural messaging. Primary self-report outcomes included receptivity to antibody testing, as well as activation of medical mistrust and concern for rural-discrimination in future SARS-CoV-2 antibody testing. We also developed and provided an opportunity to participate in a home-based salivary antibody screening program. In addition to assessing the feasibility and fidelity of this program, we assessed interest and full participation in the serosurveillance program as behavioral outcomes.

Discussion

Findings from this study can guide the use of home-based screening programs and targeted health communication strategies to promote greater uptake of health resources in rural communities. In doing so, study results can also guide public health strategies to reduce pandemic-related and other rural health disparities.

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农村定向信息传递、多重唾液测量和SARS-CoV-2抗体检测中的农村公平性：一项SeroNet调查的方案概述

农村社区受到COVID-19大流行的影响尤为严重。血清学（抗体）检测有助于农村地区当前和未来的大流行防范工作。然而，由于难以到达的农村地区能否获得血清学检测资源，以及许多农村社区可能对使用血清学检测资源犹豫不决，因此，从血清监测中获得的益处受到了挑战。需要进行试验，以评估能够提高农村对服务监测接受程度的外联和卫生传播战略。方法我们进行了一项两组随机对照试验，从密歇根州北部农村招募了N = 194名参与者。在一次持续约45分钟的在线会议中，参与者被随机分配观看一般的SARS-CoV-2抗体检测教学视频，或与农村社区咨询委员会共同制作的针对农村的教学视频，其中包含独特的农村信息。自我报告的主要结果包括对抗体检测的接受程度，以及在未来的SARS-CoV-2抗体检测中引发的医疗不信任和对农村歧视的担忧。我们还开发并提供了一个参与家庭唾液抗体筛查项目的机会。除了评估该计划的可行性和保真度外，我们还评估了对服务监测计划的兴趣和充分参与作为行为结果。讨论本研究的发现可以指导家庭筛查项目和有针对性的健康传播策略的使用，以促进农村社区更多地利用卫生资源。这样，研究结果还可以指导公共卫生战略，以减少与大流行病有关的差距和其他农村保健差距。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contemporary Clinical Trials Communications Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

2.70

自引率

6.70%

发文量

146

审稿时长

20 weeks

期刊介绍： Contemporary Clinical Trials Communications is an international peer reviewed open access journal that publishes articles pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from a wide range of disciplines including medicine, life science, pharmaceutical science, biostatistics, epidemiology, computer science, management science, behavioral science, and bioethics. Contemporary Clinical Trials Communications is unique in that it is outside the confines of disease specifications, and it strives to increase the transparency of medical research and reduce publication bias by publishing scientifically valid original research findings irrespective of their perceived importance, significance or impact. Both randomized and non-randomized trials are within the scope of the Journal. Some common topics include trial design rationale and methods, operational methodologies and challenges, and positive and negative trial results. In addition to original research, the Journal also welcomes other types of communications including, but are not limited to, methodology reviews, perspectives and discussions. Through timely dissemination of advances in clinical trials, the goal of Contemporary Clinical Trials Communications is to serve as a platform to enhance the communication and collaboration within the global clinical trials community that ultimately advances this field of research for the benefit of patients.