A novel multilayered drug-releasing stent for actively accelerating thrombosis in aneurysm therapy

IF 1 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical hypotheses Pub Date : 2026-04-01 Epub Date: 2026-03-01 DOI:10.1016/j.mehy.2026.111930

Peng Zhang , Xiaoyan Deng , Xiao Liu , Fan Zhang , Jun Li , Chun Guo , Shangming Liu

引用次数: 0

Abstract

Current endovascular treatments such as flow diverters promote aneurysm occlusion through passive changes in blood flow, but are limited by a high-risk transition period during which delayed thrombus formation may lead to sac enlargement and rupture. We hypothesize that engineering a porous stent with a localized, controlled-release system for pro-thrombotic agents can actively accelerate the formation of stable thrombus, thereby mitigating this risk. The proposed stent device combines flow stagnation via overlapping struts, a structural support for endothelialization, and targeted delivery of thrombotic agents into the aneurysm sac. If confirmed, this approach may introduce a new treatment strategy that combines device design with targeted drug therapy to improve occlusion effectiveness and patient safety.

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一种新型多层药物释放支架在动脉瘤治疗中积极加速血栓形成

目前的血管内治疗，如分流器，通过被动改变血流促进动脉瘤闭塞，但受限于高风险过渡期，延迟血栓形成可能导致囊增大和破裂。我们假设，设计一种具有局部、促血栓药物控释系统的多孔支架可以积极地加速稳定血栓的形成，从而降低这种风险。提出的支架装置结合了通过重叠支柱的血流停滞，内皮化的结构支持，以及将血栓形成剂靶向递送到动脉瘤囊中。如果得到证实，该方法可能会引入一种新的治疗策略，将设备设计与靶向药物治疗相结合，以提高闭塞效果和患者安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical hypotheses 医学-医学：研究与实验

CiteScore

10.60

自引率

2.10%

发文量

167

审稿时长

60 days

期刊介绍： Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.