Efficacy and predictive criteria for success of photobiomodulation therapy in women presenting with vulvar and vaginal pain.

IF 1.2
The French journal of urology Pub Date : 2026-10-01 Epub Date: 2026-03-03 DOI:10.1016/j.fjurol.2026.103095
Catlyne Plumasseau, Mathilde Lepelletier, Sarah Vieillefosse, Pierre Millet, Roxane Haziza, Eleonora Salakos, Antony Tuil, Jeremie Mattern, Xavier Deffieux
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Abstract

Objective: Vulvar and vaginal pain is a frequent complaint that may have psychological consequences. Treatments such as muscle relaxation physiotherapy, sophrology, and photobiomodulation (PBM)/low-intensity laser therapy (LLT) are used, but there are a few data concerning the efficacy of PBM/LLT. The objective of the current study was to assess the effectiveness and the predictive factors associated with the success of PBM/LLT in women presenting with vulvar and vaginal pain.

Method: Success was defined as a Patient Global Impression of Improvement (PGI-I) of 1 or 2. A single-center, retrospective, observational study (cohort study) was conducted on 52 women, 27 of whom were in the success group and 25 in the failure group. Patients had 6 to 8 PBM/LLT sessions with an endovaginal probe and completed pre- and post-therapy questionnaires. The analysis was carried out on the various recorded characteristics.

Results: The overall success rate was 52%. The univariate analysis significantly revealed less burning pain in the success group (OR 0.13; 95% CI: 0.02, 0.62). There were also more patients without vaginal atrophy and non-menopausal women in the success group (OR 0.21; 95% CI: 0.04-0.82 for both). However, the multivariate analysis did not show any significant difference for any predictive factor.

Conclusion: We observed a moderate success rate associated with PBM/LLT in women presenting with vulvar and vaginal pain. Multivariate analysis revealed no predictive factor for success.

Level of evidence: 4:

以外阴和阴道疼痛为表现的女性光生物调节治疗成功的疗效和预测标准。
目的:外阴和阴道疼痛是一种常见的主诉,可能会产生心理后果。治疗方法如肌肉放松物理疗法、神经学和光生物调节(PBM)/低强度激光治疗(LLT)被使用,但关于PBM/LLT的疗效的数据很少。本研究的目的是评估PBM/LLT治疗外阴和阴道疼痛的有效性和预测因素。方法:患者总体印象改善(PGI-I)为1或2,即为成功。本研究对52名女性进行了单中心、回顾性、观察性研究(队列研究),其中成功组27例,失败组25例。患者接受6 - 8次阴道内探针PBM/LLT治疗,并完成治疗前和治疗后问卷调查。对所记录的各种特征进行了分析。结果:总成功率为52%。单因素分析显著显示,成功组灼痛减轻(OR 0.13; 95% CI: 0.02, 0.62)。在成功组中,无阴道萎缩的患者和非绝经期妇女也更多(OR 0.21; 95% CI: 0.04-0.82)。然而,多变量分析没有显示任何预测因素有显著差异。结论:我们观察到,在外阴和阴道疼痛的女性中,PBM/LLT的成功率中等。多变量分析显示没有预测成功的因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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