Surgical complications following pancreaticoduodenectomy in pancreatic neuroendocrine tumors: A systematic review

IF 2.3 4区医学 Q2 SURGERY

Journal of Visceral Surgery Pub Date : 2026-10-01 Epub Date: 2026-03-04 DOI:10.1016/j.jviscsurg.2025.12.002

Donavan S. O’Brien, Henyah W. Dardir, Ahmed Adham R. Elsayed, Marc D. Basson

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引用次数: 0

Abstract

Background

The management of pancreatic tumors varies depending on the tissue origin, as the tissue type results in numerous differences in the tumor's behavior. Pancreatic neuroendocrine tumors (pNETs) arise from pancreatic islet cells, distinguishing them from pancreatic adenocarcinomas that arise from glandular tissue. Pancreatic neuroendocrine tumors are frequently resected by pancreaticoduodenectomy. This review examines complications of pancreaticoduodenectomy in patients with pancreatic neuroendocrine tumors.

Methods

PubMed, Cochrane, Virtual Health Library, and Web of Science databases were searched for studies reporting intraoperative and postoperative complications following the resection of pNETs via pancreaticoduodenectomy. Studies that met the inclusion criteria underwent quality assessment via STROBE and CARE guidelines for observational studies and case reports, respectively.

Results

Our search yielded 42 articles with a total relevant population of 2925. The main intraoperative complication (6.43%) was blood loss requiring blood transfusions (5.61%). Postoperative complications (55.38%) included pancreatic fistula (POPF) (21.23%), postoperative bleeding (0.31%), pancreatic hemorrhage (1.16%), delayed gastric emptying (3.90%), surgical site infection (2.02%), organ/space infection (6.36%) abdominal abscess (3.08%), bile fistula (0.72%), biliary stricture (0.068%), chyle leak (0.21), pancreatitis (0.034%) and other/unspecified complications (15%).

Conclusion

The postoperative complication rate for pancreaticoduodenectomy is 55.38%, with POPF being the most common. Patients with pNETs are significantly more likely to experience POPF than any other pancreatic pathology, including pancreatic adenocarcinoma. Patients with pancreatic neuroendocrine tumors are at higher risk for pancreatic fistulas due to the tumor's origin in soft pancreatic tissue and a small Wirsung duct. Pancreaticoduodenectomy is preferred for tumors larger than 2 cm or close to the duct.

查看原文本刊更多论文

胰十二指肠切除术后胰腺神经内分泌肿瘤的手术并发症：系统回顾。

背景：胰腺肿瘤的治疗取决于组织来源，因为组织类型导致肿瘤行为的许多差异。胰腺神经内分泌肿瘤（pNETs）起源于胰岛细胞，区别于起源于腺组织的胰腺腺癌。胰腺神经内分泌肿瘤常通过胰十二指肠切除术切除。本文回顾胰十二指肠切除术治疗胰神经内分泌肿瘤的并发症。方法：检索PubMed、Cochrane、虚拟健康图书馆和Web of Science数据库，检索经胰十二指肠切除术切除pNETs术中和术后并发症的研究报告。符合纳入标准的研究分别通过STROBE和CARE观察性研究指南和病例报告进行质量评估。结果：我们检索到42篇文章，总相关人群为2925人。术中主要并发症为失血（6.43%），需输血（5.61%）。术后并发症包括胰瘘（POPF）（21.23%）、术后出血（0.31%）、胰腺出血（1.16%）、胃排空延迟（3.90%）、手术部位感染（2.02%）、器官/间隙感染（6.36%）、腹部脓肿（3.08%）、胆瘘（0.72%）、胆道狭窄（0.068%）、乳糜漏（0.21%）、胰腺炎（0.034%）和其他/未明确并发症（15%），占55.38%。结论：胰十二指肠切除术术后并发症发生率为55.38%，以POPF最常见。与其他胰腺病理（包括胰腺腺癌）相比，pNETs患者更容易发生POPF。由于胰腺神经内分泌肿瘤起源于胰腺软组织和较小的Wirsung管，因此患者发生胰瘘的风险较高。对于大于2cm或靠近胰管的肿瘤，首选胰十二指肠切除术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Visceral Surgery SURGERY-

CiteScore

2.00

自引率

9.50%

发文量

108

审稿时长

>12 weeks

期刊介绍： The Journal of Visceral Surgery (JVS) is the online-only, English version of the French Journal de Chirurgie Viscérale. The journal focuses on clinical research and continuing education, and publishes original and review articles related to general surgery, as well as press reviews of recently published major international works. High-quality illustrations of surgical techniques, images and videos serve as support for clinical evaluation and practice optimization. JVS is indexed in the main international databases (including Medline) and is accessible worldwide through ScienceDirect and ClinicalKey.