Simona Maccora, Sabrina Sacconi, Nicolas Azulay, Mihai Bogdan Ioncea, Andra Ezaru, Michele Cavalli, Luisa Villa, Giulia Tammam, Charles Raffaelli, Angela Puma
{"title":"Not only cross-sectional area: Echogenicity matters in nerve ultrasound studies of patients with motor multifocal neuropathy.","authors":"Simona Maccora, Sabrina Sacconi, Nicolas Azulay, Mihai Bogdan Ioncea, Andra Ezaru, Michele Cavalli, Luisa Villa, Giulia Tammam, Charles Raffaelli, Angela Puma","doi":"10.1177/22143602261426071","DOIUrl":null,"url":null,"abstract":"<p><p>Nerve ultrasound (n-US) supports the diagnosis of multifocal motor neuropathy (MMN), though most studies focus on nerve enlargement (NE) and its distribution. This study explored nerve echotexture using ultrahigh-frequency ultrasound (UH-FUS) in 13 MMN patients (mean age 61.9 years, disease duration 147 ± 105 months). NE was detected in 77%, preferentially involving median nerve, yet conduction blocks corresponded to NE in only 15%. Notably, 92% showed mixed/hyperechoic echotexture, including three patients with normal CSA, suggesting microstructural remodeling beyond swelling. No hypoechoic nerves were observed, consistent with limited acute inflammation. Combining echogenicity with NE assessment may improve n-US sensitivity, especially in atypical MMN.</p>","PeriodicalId":16536,"journal":{"name":"Journal of neuromuscular diseases","volume":" ","pages":"1134-1139"},"PeriodicalIF":3.5000,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13437737/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of neuromuscular diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/22143602261426071","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/3/4 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Nerve ultrasound (n-US) supports the diagnosis of multifocal motor neuropathy (MMN), though most studies focus on nerve enlargement (NE) and its distribution. This study explored nerve echotexture using ultrahigh-frequency ultrasound (UH-FUS) in 13 MMN patients (mean age 61.9 years, disease duration 147 ± 105 months). NE was detected in 77%, preferentially involving median nerve, yet conduction blocks corresponded to NE in only 15%. Notably, 92% showed mixed/hyperechoic echotexture, including three patients with normal CSA, suggesting microstructural remodeling beyond swelling. No hypoechoic nerves were observed, consistent with limited acute inflammation. Combining echogenicity with NE assessment may improve n-US sensitivity, especially in atypical MMN.
期刊介绍：
The Journal of Neuromuscular Diseases aims to facilitate progress in understanding the molecular genetics/correlates, pathogenesis, pharmacology, diagnosis and treatment of acquired and genetic neuromuscular diseases (including muscular dystrophy, myasthenia gravis, spinal muscular atrophy, neuropathies, myopathies, myotonias and myositis). The journal publishes research reports, reviews, short communications, letters-to-the-editor, and will consider research that has negative findings. The journal is dedicated to providing an open forum for original research in basic science, translational and clinical research that will improve our fundamental understanding and lead to effective treatments of neuromuscular diseases.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
