Comparison of Pediatric and Adult Glucagon-Like Peptide-1 Receptor Agonist Exposures Reported To United States Poison Centers, 2017-2024.

IF 2 4区医学 Q3 TOXICOLOGY

Journal of Medical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-03-05 DOI:10.1007/s13181-026-01128-6

Anjali Senthilkumar, Hannah L Hays, Sandhya Kistamgari, Natalie I Rine, Allison L Rhodes, Christopher E Gaw, Gary A Smith

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引用次数: 0

Abstract

Introduction: As glucagon-like peptide-1 receptor agonist (GLP-1) use has increased among children, a better understanding of the related adverse effects in this population is needed.

Methods: National Poison Data System data from 2017 to 2024 were analyzed to compare characteristics and trends of exposures involving GLP-1s reported to United States (US) poison centers (PCs) among children 6-17 years old with those of adults.

Results: There were 13,924 single-substance GLP-1 exposures reported to US PCs from 2017 to 2024. The rate of exposures per one million US population increased by 1,830.8% from 0.97 in 2017 to 18.79 in 2024, including a 4,805.0% increase among children 6-17 years old from 0.04 in 2017 to 1.97 in 2024, with the majority of the increase occurring after 2021. Most exposures (91.7%) were associated with no or mild effects, while moderate effects were observed in 8.0% and major effects occurred in 42 exposures; there were two deaths. Children 6-17 years old were more likely (RR: 2.66, 95% CI: 1.73-4.11) to be admitted than adults, and children 12-17 years old were more likely (RR: 1.68, 95% CI: 1.08-2.63) to experience a more serious medical outcome than adults. Children 6-17 years old with at least one clinical effect experienced vomiting (88.2%) more commonly than adults (61.3%) (RR: 1.44, 95% CI: 1.34-1.55). Additionally, exposures among children 6-17 years old were more likely to be attributable to intentional misuse (RR: 8.12, 95% CI: 6.47-10.17) than among adults.

Conclusions: This study provides national-level, real-world findings that may help inform clinical practice.

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2017-2024年美国中毒中心报告的儿童和成人胰高血糖素样肽-1受体激动剂暴露比较

随着儿童中胰高血糖素样肽-1受体激动剂（GLP-1）的使用增加，需要更好地了解该人群的相关不良反应。方法：分析2017年至2024年美国国家毒物数据系统（National Poison Data System）数据，比较美国毒物中心（PCs）报告的6-17岁儿童与成人glp -1暴露的特征和趋势。结果：2017年至2024年，美国pc报告了13924例单一物质GLP-1暴露。每百万美国人口的暴露率从2017年的0.97增加到2024年的18.79，增加了1830.8%，其中6-17岁儿童的暴露率从2017年的0.04增加到2024年的1.97，增加了4805.0%，其中大部分增加发生在2021年之后。大多数暴露（91.7%）与无影响或轻度影响相关，而8.0%的暴露观察到中度影响，42次暴露发生了主要影响；有两人死亡。6-17岁的儿童比成人更有可能入院（RR: 2.66, 95% CI: 1.73-4.11）， 12-17岁的儿童比成人更有可能经历更严重的医疗结果（RR: 1.68, 95% CI: 1.08-2.63）。至少有一种临床效应的6-17岁儿童（88.2%）比成人（61.3%）更常见呕吐（RR: 1.44, 95% CI: 1.34-1.55）。此外，6-17岁儿童的暴露更可能归因于故意滥用（RR: 8.12, 95% CI: 6.47-10.17）。结论：这项研究提供了国家级的、现实世界的发现，可能有助于告知临床实践。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Toxicology TOXICOLOGY-

CiteScore

5.40

自引率

10.30%

发文量

期刊介绍： Journal of Medical Toxicology (JMT) is a peer-reviewed medical journal dedicated to advances in clinical toxicology, focusing on the diagnosis, management, and prevention of poisoning and other adverse health effects resulting from medications, chemicals, occupational and environmental substances, and biological hazards. As the official journal of the American College of Medical Toxicology (ACMT), JMT is managed by an editorial board of clinicians as well as scientists and thus publishes research that is relevant to medical toxicologists, emergency physicians, critical care specialists, pediatricians, pre-hospital providers, occupational physicians, substance abuse experts, veterinary toxicologists, and policy makers. JMT articles generate considerable interest in the lay media, with 2016 JMT articles cited by various social media sites, the Boston Globe, and the Washington Post among others. For questions or comments about the journal, please contact jmtinfo@acmt.net. For questions or comments about the journal, please contact jmtinfo@acmt.net.