{"title":"Xenotransplantation and the organ shortage: evaluating policy priorities.","authors":"Jessica S Kopew, Jarrod Bailey, Catharine E Krebs","doi":"10.1097/MOT.0000000000001270","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>Xenotransplantation has emerged as a popular potential solution for increasing organ supply, but it comes with formidable public health risks and ethical harms. The purpose of this review is to evaluate xenotransplantation and other strategies for addressing the organ shortage, pointing toward the most promising policy priorities.</p><p><strong>Recent findings: </strong>Advances in genetic engineering, paired with increasing financial support, have positioned xenotransplantation in its first ever clinical trials. Rejection remains a formidable challenge, and caution prevails as the full breadth of zoonotic infectious potential remains to be determined. Meanwhile, strategies have been implemented around the world to bolster allotransplant organ supply and practices and to better treat chronic diseases to reduce demand for organs.</p><p><strong>Summary: </strong>With more support and broader global adoption, these alternative strategies can address the organ shortage more effectively, safely, and ethically than xenotransplantation and should be prioritized by policymakers.</p>","PeriodicalId":10900,"journal":{"name":"Current Opinion in Organ Transplantation","volume":"31 2","pages":"105-109"},"PeriodicalIF":2.5000,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978718/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Organ Transplantation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MOT.0000000000001270","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/2/3 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"TRANSPLANTATION","Score":null,"Total":0}
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Abstract
Purpose of review: Xenotransplantation has emerged as a popular potential solution for increasing organ supply, but it comes with formidable public health risks and ethical harms. The purpose of this review is to evaluate xenotransplantation and other strategies for addressing the organ shortage, pointing toward the most promising policy priorities.
Recent findings: Advances in genetic engineering, paired with increasing financial support, have positioned xenotransplantation in its first ever clinical trials. Rejection remains a formidable challenge, and caution prevails as the full breadth of zoonotic infectious potential remains to be determined. Meanwhile, strategies have been implemented around the world to bolster allotransplant organ supply and practices and to better treat chronic diseases to reduce demand for organs.
Summary: With more support and broader global adoption, these alternative strategies can address the organ shortage more effectively, safely, and ethically than xenotransplantation and should be prioritized by policymakers.
期刊介绍：
Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.
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