Vitamin E and heart disease: a thematic systematic review.

IF 2.5 4区医学 Q3 HEALTH CARE SCIENCES & SERVICES

BMJ Supportive & Palliative Care Pub Date : 2026-08-28 DOI:10.1136/spcare-2025-005637

Kimia Sharifi, Sima Rafiei, Maryam Masoumi, Mehrshad Sebti, Saba Rabiee, Saghar Khani, Golnaz Kheradkhah, Ahmad Ghashghaee

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引用次数: 0

Abstract

Introduction: The majority of observational studies approved that regular consumption of vitamin E would decrease the risk of cardiovascular events. However, a great number of randomised trials do not support this idea and dismiss the beneficial effect of vitamin E in reducing heart disease risk factors.

Methods: To test this hypothesis and identify whether vitamin E supplementation can reduce the risks of cardiovascular diseases, we organised a systematic review to reach out relevant articles. Insert the authors' criteria for inclusion and exclusion of studies; 58 papers were remained in the review.

Results: Some of the studies revealed a significant role of vitamin E in preventing CVD, while almost all of the trials suggested no beneficial impact of vitamin E on cardiovascular outcomes. Thus, there is a need for further studies to be conducted in the field.

Conclusion: It is recommended to critically review the results of randomised trials based on a wide range of different parameters, including the form of vitamin E, the duration and dosage of vitamin E consumption, and the synergetic effects of vitamin E with other antioxidants or medication. The intervention studies also need to be considered in terms of specific clinical settings and be improved through successful study designs.

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维生素E与心脏病：专题系统综述。

导读：大多数观察性研究证实，经常摄入维生素E可以降低心血管事件的风险。然而，大量的随机试验并不支持这一观点，并否定了维生素E在减少心脏病风险因素方面的有益作用。方法：为了验证这一假设，并确定补充维生素E是否可以降低心血管疾病的风险，我们组织了一项系统综述，以获取相关文章。插入作者纳入和排除研究的标准；58篇论文仍在评审中。结果：一些研究揭示了维生素E在预防心血管疾病方面的重要作用，而几乎所有的试验都表明维生素E对心血管疾病没有有益的影响。因此，有必要在这一领域进行进一步的研究。结论：建议对随机试验的结果进行严格审查，这些随机试验的参数范围很广，包括维生素E的形式、维生素E摄入的持续时间和剂量，以及维生素E与其他抗氧化剂或药物的协同作用。干预研究还需要考虑具体的临床环境，并通过成功的研究设计加以改进。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMJ Supportive & Palliative Care Medicine-Medicine (miscellaneous)

CiteScore

4.60

自引率

7.40%

发文量

170

期刊介绍： Published quarterly in print and continuously online, BMJ Supportive & Palliative Care aims to connect many disciplines and specialties throughout the world by providing high quality, clinically relevant research, reviews, comment, information and news of international importance. We hold an inclusive view of supportive and palliative care research and we are able to call on expertise to critique the whole range of methodologies within the subject, including those working in transitional research, clinical trials, epidemiology, behavioural sciences, ethics and health service research. Articles with relevance to clinical practice and clinical service development will be considered for publication. In an international context, many different categories of clinician and healthcare workers do clinical work associated with palliative medicine, specialist or generalist palliative care, supportive care, psychosocial-oncology and end of life care. We wish to engage many specialties, not only those traditionally associated with supportive and palliative care. We hope to extend the readership to doctors, nurses, other healthcare workers and researchers in medical and surgical specialties, including but not limited to cardiology, gastroenterology, geriatrics, neurology, oncology, paediatrics, primary care, psychiatry, psychology, renal medicine, respiratory medicine.