Enzyme-Triggered Synthesis and Functionalization of Five-Membered Nitrogen Atom(s) Containing Heterocycles

IF 2.3 4区 化学 Q3 CHEMISTRY, PHYSICAL
Shivangi Jaiswal, Annu Bhardwaj, Jaya Dwivedi, Swapnil Sharma
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引用次数: 0

Abstract

Nitrogen heterocycles are ubiquitous, found in a wide range of natural products, pharmaceuticals, and industrial chemicals. Inspired by the ingenuity of nitrogen heterocycles in nature, the facile and efficient synthesis of heterocycles requires considerable attention from the investigator. Recently, the application of enzymes has been explored for the synthesis of a wide range of chemicals, natural products, synthetic building blocks, and bioactive agents. This review summarizes the latest reports on the enzyme-triggered reaction for the green synthesis of various five-membered nitrogen heterocycles, including pyrrole, pyrazole, imidazole, triazole, and tetrazole, between 2005 and 2025. Additionally, the role of enzyme catalysis in the development of various therapeutic agents has been highlighted, encompassing the latest updates.

Graphical Abstract

含杂环五元氮原子的酶促合成与功能化
氮杂环无处不在,广泛存在于天然产物、药品和工业化学品中。受到自然界氮杂环的精巧性的启发,杂环的简便高效的合成需要研究者给予相当的重视。近年来,酶的应用被广泛地应用于化学物质、天然产物、合成构件和生物活性物质的合成。本文综述了2005年至2025年国内外关于绿色合成吡咯、吡唑、咪唑、三唑、四唑等五元氮杂环的酶促反应的最新报道。此外,还强调了酶催化在各种治疗剂开发中的作用,包括最新的更新。图形抽象
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Catalysis Surveys from Asia
Catalysis Surveys from Asia 化学-物理化学
CiteScore
4.80
自引率
0.00%
发文量
29
审稿时长
>12 weeks
期刊介绍: Early dissemination of important findings from Asia which may lead to new concepts in catalyst design is the main aim of this journal. Rapid, invited, short reviews and perspectives from academia and industry will constitute the major part of Catalysis Surveys from Asia . Surveys of recent progress and activities in catalytic science and technology and related areas in Asia will be covered regularly as well. We would appreciate critical comments from colleagues throughout the world about articles in Catalysis Surveys from Asia . If requested and thought appropriate, the comments will be included in the journal. We will be very happy if this journal stimulates global communication between scientists and engineers in the world of catalysis.
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