pH‐responsive supramolecular vesicles composed of sulfobutylether‐β‐cyclodextrin and N‐dodecyl chitosan for controlled release of naproxen sodium

IF 3.6 4区工程技术 Q2 ENGINEERING, CHEMICAL

Polymer Engineering and Science Pub Date : 2025-04-03 DOI:10.1002/pen.27202

Hai‐Bin Luo, Wen‐Rong Xu

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引用次数: 0

Abstract

Abstract pH‐responsive supramolecular polymeric vesicles were successfully developed through the host–guest complexation of two biocompatible and water‐soluble saccharides: sulfobutylether‐β‐cyclodextrin (SCD) and N ‐dodecyl chitosan (DCS). Extensive characterization using UV–vis spectroscopy, dynamic light scattering (DLS), zeta potential measurements, and transmission electron microscopy (TEM) confirmed the structural robustness of the vesicles, which exhibited effective self‐assembly in acidic conditions and disassembly in alkaline environments. To evaluate the drug‐loading capacity and pH‐responsive release properties, naproxen sodium (NS), a widely used nonsteroidal anti‐inflammatory drug, was encapsulated as a model compound. In vitro release studies simulating gastrointestinal pH conditions (2.0, 6.8, and 8.5) demonstrated minimal drug release of (28.34 ± 1.02)% at low pH and significantly enhanced release of (56.57 ± 1.68)% and (86.96 ± 1.29)% at neutral and slightly alkaline pH, respectively. The system exhibited an initial burst release followed by sustained release, aligning with the therapeutic requirements for rapid onset and prolonged action. These findings highlight the potential of SCD/DCS supramolecular vesicles as a versatile platform for targeted oral drug delivery, particularly for drugs requiring intestinal release. Highlights Supramolecular vesicles self‐assembled via sulfobutylether‐β‐cyclodextrin (SCD) and N ‐dodecyl chitosan (DCS) host–guest complexation. Vesicles exhibited stability in acidic pH and disassembled in alkaline conditions. Naproxen sodium‐loaded vesicles displayed pH‐sensitive release properties. Drug release occurred in neutral to alkaline pH, ideal for intestinal delivery.

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巯基丁醚- β -环糊精和N -十二烷基壳聚糖组成的pH响应超分子囊泡，用于萘普生钠的控释

摘要/ Abstract摘要：通过对两种生物相容性和水溶性糖类：磺基丁醚- β -环糊精（SCD）和N -十二烷基壳聚糖（DCS）的主客体络合，成功制备了pH响应的超分子聚合物囊泡。利用紫外可见光谱、动态光散射（DLS）、zeta电位测量和透射电子显微镜（TEM）进行了广泛的表征，证实了这些囊泡的结构坚固性，它们在酸性条件下表现出有效的自组装，在碱性环境下表现出有效的自组装。为了评估其载药能力和pH响应性释放特性，我们将广泛使用的非甾体抗炎药萘普生钠（NS）包封为模型化合物。模拟胃肠道pH值（2.0、6.8和8.5）的体外释放研究表明，低pH条件下药物释放量最小，为（28.34±1.02）%，而在中性和微碱性条件下，药物释放量分别显著增加，为（56.57±1.68）%和（86.96±1.29）%。该系统表现出最初的爆发性释放，随后持续释放，符合快速起效和延长作用的治疗要求。这些发现强调了SCD/DCS超分子囊泡作为靶向口服药物递送的多功能平台的潜力，特别是对于需要肠道释放的药物。通过巯基丁醚- β -环糊精（SCD）和N -十二烷基壳聚糖（DCS）主客体络合自组装的超分子囊泡。囊泡在酸性条件下表现出稳定性，在碱性条件下会解体。钠负载的萘普生囊泡显示出pH敏感的释放特性。药物释放发生在中性到碱性的pH值，非常适合肠道给药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Polymer Engineering and Science 工程技术-高分子科学

CiteScore

5.40

自引率

18.80%

发文量

329

审稿时长

3.7 months

期刊介绍： For more than 30 years, Polymer Engineering & Science has been one of the most highly regarded journals in the field, serving as a forum for authors of treatises on the cutting edge of polymer science and technology. The importance of PE&S is underscored by the frequent rate at which its articles are cited, especially by other publications - literally thousand of times a year. Engineers, researchers, technicians, and academicians worldwide are looking to PE&S for the valuable information they need. There are special issues compiled by distinguished guest editors. These contain proceedings of symposia on such diverse topics as polyblends, mechanics of plastics and polymer welding.

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naproxen sodium
26159-34-2

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