Programming Ordered Tissue Reconstruction via Artificial Bionic Tendon Sheath for Tendinopathy Treatment

IF 22.6 1区工程技术 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Advanced Fiber Materials Pub Date : 2025-12-01 DOI:10.1007/s42765-025-00637-3

Chao Li, Wentao Li, Ronghui Deng, Lingan Huang, Yifan Song, Xianjie Wei, Bingbing Xu, Guoqing Cui, Zehao Chen, Jiakuo Yu

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Abstract

Excessive interface friction and advanced glycation end products (AGEs) disrupt collagen ordered deposition, promoting scar formation in tendinopathies. Inspired by tendon sheath anatomy, we developed a bionic bilayer nano-membrane via electrospinning and photocrosslinking to initiate the directional and orderly regeneration process of tendon tissue. The lubricating layer (PP), containing phosphatidylserine (PS), reduces frictional stress, while the regenerative layer (GM/GV), composed of gelatin methacrylate (GM) and vanillin-modified gelatin (GV), scavenges ROS and mitigates AGEs-induced collagen disorder deposition. This parallel bilayer structure guides tendon cell alignment and promotes ordered collagen deposition. Additionally, vanillin suppresses the AGEs/TGF-β/Smad pathway, reducing scar formation and tissue adhesion. In vitro/in vivo tests showed a fivefold decrease in coefficient of friction (COF) and a tenfold increase in Achilles tendon function index (AFI) compared to the PCL and normal groups, respectively. The PP@GM/GV membrane, regulated by mechano-biochemical coupling factors, offers a promising strategy for tendinopathy repair, and holds significant potential for clinical translation in guiding functional tendon regeneration and improving patient outcomes.

Graphical Abstract

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利用人工仿生肌腱鞘规划有序组织重建治疗肌腱病

过度的界面摩擦和晚期糖基化终产物（AGEs）破坏胶原有序沉积，促进肌腱病变中瘢痕的形成。受肌腱鞘解剖的启发，我们通过静电纺丝和光交联开发了一种仿生双层纳米膜，以启动肌腱组织的定向和有序再生过程。含有磷脂酰丝氨酸（PS）的润滑层（PP）可降低摩擦应力，而由甲基丙烯酸明胶（GM）和香草素修饰明胶（GV）组成的再生层（GM/GV）可清除活性氧并减轻ages诱导的胶原蛋白紊乱沉积。这种平行的双层结构引导肌腱细胞排列并促进有序的胶原沉积。此外，香兰素抑制AGEs/TGF-β/Smad通路，减少疤痕形成和组织粘连。体外/体内试验显示，与PCL组和正常组相比，摩擦系数（COF）降低了5倍，跟腱功能指数（AFI）增加了10倍。PP@GM/GV膜受机械-生化偶联因子的调控，为肌腱病变修复提供了一种有希望的策略，并在指导功能性肌腱再生和改善患者预后方面具有重要的临床转化潜力。图形抽象

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来源期刊

Advanced Fiber Materials Multiple-

CiteScore

18.70

自引率

11.20%

发文量

109

期刊介绍： Advanced Fiber Materials is a hybrid, peer-reviewed, international and interdisciplinary research journal which aims to publish the most important papers in fibers and fiber-related devices as well as their applications.Indexed by SCIE, EI, Scopus et al. Publishing on fiber or fiber-related materials, technology, engineering and application.

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