Selective tumor accumulation as a route to precision medicine for platinum anticancer drugs

IF 3.2 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Inorganic Biochemistry Pub Date : 2026-06-01 Epub Date: 2026-02-20 DOI:10.1016/j.jinorgbio.2026.113267

Erica J. Peterson, Nicholas P. Farrell

引用次数: 0

Abstract

This brief review summarizes our work showing that glycosaminoglycans (GAGs) are mediators of platinum complex cellular accumulation. Especially, there is an inverse relationship whereby charged polynuclear platinum complexes exemplified by BBR3464 and BBR3571 show enhanced tumor accumulation and antitumor efficacy in presence of a high level of GAGs whereas the inverse relationship occurs for the neutral mononuclear carboplatin. These results add to our understanding of the tumor uptake of platinum anticancer drugs and suggest avenues toward precision medicine for platinums based on patient stratification.

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选择性肿瘤蓄积作为铂类抗癌药物精准用药的途径。

本文简要综述了糖胺聚糖（GAGs）是铂复合物细胞积累的介质。特别是，带电多核铂配合物（如BBR3464和BBR3571）在高水平GAGs存在时表现出增强的肿瘤积累和抗肿瘤功效，而中性单核卡铂则呈反比关系。这些结果增加了我们对铂类抗癌药物的肿瘤摄取的理解，并为基于患者分层的铂类精准医学提供了途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Inorganic Biochemistry 生物-生化与分子生物学

CiteScore

7.00

自引率

10.30%

发文量

336

审稿时长

41 days

期刊介绍： The Journal of Inorganic Biochemistry is an established international forum for research in all aspects of Biological Inorganic Chemistry. Original papers of a high scientific level are published in the form of Articles (full length papers), Short Communications, Focused Reviews and Bioinorganic Methods. Topics include: the chemistry, structure and function of metalloenzymes; the interaction of inorganic ions and molecules with proteins and nucleic acids; the synthesis and properties of coordination complexes of biological interest including both structural and functional model systems; the function of metal- containing systems in the regulation of gene expression; the role of metals in medicine; the application of spectroscopic methods to determine the structure of metallobiomolecules; the preparation and characterization of metal-based biomaterials; and related systems. The emphasis of the Journal is on the structure and mechanism of action of metallobiomolecules.