Connie H Chung, Jason R Barash, Jacquelin L Castonguay, Claire Penzel-McNamara, Katie Lee, Jennifer S Read, Kerry A Padgett, Nir Dover, Aaron J Judson, Liz Lamere, Ethel V Taylor, Jennifer R Cope, Amanda Conrad, Rochelle Medford, Myra Brooks, Laura Whitlock, Janet Dykes, Carolina Lúquez, Julia M Bracken, Steven M Grube, Jessica M Khouri
{"title":"Multistate Infant Botulism Outbreak Associated with Powdered Infant Formula.","authors":"Connie H Chung, Jason R Barash, Jacquelin L Castonguay, Claire Penzel-McNamara, Katie Lee, Jennifer S Read, Kerry A Padgett, Nir Dover, Aaron J Judson, Liz Lamere, Ethel V Taylor, Jennifer R Cope, Amanda Conrad, Rochelle Medford, Myra Brooks, Laura Whitlock, Janet Dykes, Carolina Lúquez, Julia M Bracken, Steven M Grube, Jessica M Khouri","doi":"10.1056/EVIDpha2600020","DOIUrl":null,"url":null,"abstract":"<p><p>AbstractThis report details the identification of an outbreak of infant botulism linked to powdered infant formula in the United States. In October 2025, the Infant Botulism Treatment and Prevention Program, California Department of Public Health (IBTPP-CDPH) noted common powdered infant formula exposure among three neonates with suspected infant botulism. Subsequent laboratory analyses at CDPH identified <i>Clostridium botulinum</i> type A from an open container of ByHeart powdered infant formula associated with one infant with infant botulism. As of December 10, 2025, 51 suspected or confirmed infant botulism cases with exposure to ByHeart powdered infant formula had been identified across 19 states. All ByHeart powdered infant formula has been recalled nationwide.</p>","PeriodicalId":74256,"journal":{"name":"NEJM evidence","volume":" ","pages":"EVIDpha2600020"},"PeriodicalIF":11.6000,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"NEJM evidence","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1056/EVIDpha2600020","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/2/25 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
AbstractThis report details the identification of an outbreak of infant botulism linked to powdered infant formula in the United States. In October 2025, the Infant Botulism Treatment and Prevention Program, California Department of Public Health (IBTPP-CDPH) noted common powdered infant formula exposure among three neonates with suspected infant botulism. Subsequent laboratory analyses at CDPH identified Clostridium botulinum type A from an open container of ByHeart powdered infant formula associated with one infant with infant botulism. As of December 10, 2025, 51 suspected or confirmed infant botulism cases with exposure to ByHeart powdered infant formula had been identified across 19 states. All ByHeart powdered infant formula has been recalled nationwide.
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