When persistent idiopathic facial pain is not idiopathic: Facial pain attributed to lung cancer and comparative review of classification systems.

IF 5.4 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Cranio-The Journal of Craniomandibular & Sleep Practice Pub Date : 2026-09-01 Epub Date: 2026-02-24 DOI:10.1080/08869634.2026.2632941

Shehryar N Khawaja, Madha Mansoor

{"title":"When persistent idiopathic facial pain is not idiopathic: Facial pain attributed to lung cancer and comparative review of classification systems.","authors":"Shehryar N Khawaja, Madha Mansoor","doi":"10.1080/08869634.2026.2632941","DOIUrl":null,"url":null,"abstract":"Objective: Facial pain attributed to lung cancer (FPLC) is frequently misclassified as persistent idiopathic facial pain (PIFP). This study reviewed published cases, retrospectively applied existing criteria for PIFP to evaluate misclassification, characterized clinical features of FPLC, and proposed a diagnostic framework.Methods: A structured search of MEDLINE, Embase, and Web of Science through December 13, 2025, identified 51 English-language case reports of orofacial or pharyngeal pain secondary to lung cancer. Thirty-three cases contained sufficient detail to allow retrospective application of PIFP criteria from leading classification systems.Results: Twenty-seven cases, 81.8%, met criteria for PIFP despite an underlying malignancy. Adding a requirement to exclude systemic disease substantially reduced misclassification. The proposed diagnostic criteria for FPLC demonstrated an 87.9% diagnostic accuracy.Conclusion: Idiopathic orofacial pain phenotypes overlap with FPLC. Excluding systemic causes improves the diagnostic validity of classification systems. The consistent clinical profile of FPLC supports the use of defined diagnostic criteria.","PeriodicalId":56318,"journal":{"name":"Cranio-The Journal of Craniomandibular & Sleep Practice","volume":" ","pages":"989-997"},"PeriodicalIF":5.4000,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cranio-The Journal of Craniomandibular & Sleep Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/08869634.2026.2632941","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/2/24 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Facial pain attributed to lung cancer (FPLC) is frequently misclassified as persistent idiopathic facial pain (PIFP). This study reviewed published cases, retrospectively applied existing criteria for PIFP to evaluate misclassification, characterized clinical features of FPLC, and proposed a diagnostic framework.

Methods: A structured search of MEDLINE, Embase, and Web of Science through December 13, 2025, identified 51 English-language case reports of orofacial or pharyngeal pain secondary to lung cancer. Thirty-three cases contained sufficient detail to allow retrospective application of PIFP criteria from leading classification systems.

Results: Twenty-seven cases, 81.8%, met criteria for PIFP despite an underlying malignancy. Adding a requirement to exclude systemic disease substantially reduced misclassification. The proposed diagnostic criteria for FPLC demonstrated an 87.9% diagnostic accuracy.

Conclusion: Idiopathic orofacial pain phenotypes overlap with FPLC. Excluding systemic causes improves the diagnostic validity of classification systems. The consistent clinical profile of FPLC supports the use of defined diagnostic criteria.

查看原文本刊更多论文

当持续性特发性面部疼痛不是特发性时：肺癌引起的面部疼痛和分类系统的比较回顾。

目的：肺癌引起的面部疼痛（FPLC）经常被误认为是持续性特发性面部疼痛（PIFP）。本研究回顾了已发表的病例，回顾性应用PIFP的现有标准来评估错误分类，描述了FPLC的临床特征，并提出了一个诊断框架。方法：到2025年12月13日，对MEDLINE、Embase和Web of Science进行结构化搜索，确定了51例肺癌继发的口面部或咽部疼痛的英语病例报告。33例病例包含足够的细节，允许回顾性应用领先分类系统的PIFP标准。结果：27例（81.8%）虽有潜在的恶性肿瘤，但仍符合PIFP的诊断标准。增加排除全身性疾病的要求大大减少了错误分类。提出的FPLC诊断标准的诊断准确率为87.9%。结论：特发性口面部疼痛与FPLC表型重叠。排除系统原因可以提高分类系统的诊断有效性。FPLC一致的临床特征支持使用明确的诊断标准。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cranio-The Journal of Craniomandibular & Sleep Practice DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.50

自引率

12.50%

发文量

审稿时长

>12 weeks

期刊介绍： CRANIO: The Journal of Craniomandibular & Sleep Practice is the oldest and largest journal in the world devoted to temporomandibular disorders, and now also includes articles on all aspects of sleep medicine. The Journal is multidisciplinary in its scope, with editorial board members from all areas of medicine and dentistry, including general dentists, oral surgeons, orthopaedists, radiologists, chiropractors, professors and behavioural scientists, physical therapists, acupuncturists, osteopathic and ear, nose and throat physicians. CRANIO publishes commendable works from outstanding researchers and clinicians in their respective fields. The multidisciplinary format allows individuals practicing with a TMD emphasis to stay abreast of related disciplines, as each issue presents multiple topics from overlapping areas of interest. CRANIO''s current readership (thousands) is comprised primarily of dentists; however, many physicians, physical therapists, chiropractors, osteopathic physicians and other related specialists subscribe and contribute to the Journal.