{"title":"Selective immunoglobulin E deficiency: an overlooked hypogammaglobulinemia and its association with rheumatoid arthritis.","authors":"Benedict K Tiong, Tamara Dahhan","doi":"10.1097/BOR.0000000000001150","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>As part of current rheumatoid arthritis management, immunosuppressive treatments with disease-modifying antirheumatic drugs can potentially result in needing to manage immunodeficiency in our patient population. The purpose of this review is to evaluate one specific type of hypogammaglobulinemia, selective immunoglobulin E deficiency, and examine the association with rheumatoid arthritis.</p><p><strong>Recent findings: </strong>In patients with hypogammaglobulinemia, there is consensus that autoimmunity is more prevalent, though there is heterogeneity among specific immunodeficiency disorders.</p><p><strong>Summary: </strong>Given the potential for high-risk complications associated with immunosuppressive therapies in rheumatoid arthritis and other systemic autoimmune diseases, including the risk for severe infections, furthering our understanding of the association between immunodeficiency and autoimmune disease will only allow for more thorough care of these patients.</p>","PeriodicalId":11145,"journal":{"name":"Current opinion in rheumatology","volume":" ","pages":"246-249"},"PeriodicalIF":5.4000,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in rheumatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/BOR.0000000000001150","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/2/25 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose of review: As part of current rheumatoid arthritis management, immunosuppressive treatments with disease-modifying antirheumatic drugs can potentially result in needing to manage immunodeficiency in our patient population. The purpose of this review is to evaluate one specific type of hypogammaglobulinemia, selective immunoglobulin E deficiency, and examine the association with rheumatoid arthritis.
Recent findings: In patients with hypogammaglobulinemia, there is consensus that autoimmunity is more prevalent, though there is heterogeneity among specific immunodeficiency disorders.
Summary: Given the potential for high-risk complications associated with immunosuppressive therapies in rheumatoid arthritis and other systemic autoimmune diseases, including the risk for severe infections, furthering our understanding of the association between immunodeficiency and autoimmune disease will only allow for more thorough care of these patients.
期刊介绍：
A high impact review journal which boasts an international readership, Current Opinion in Rheumatology offers a broad-based perspective on the most recent and exciting developments within the field of rheumatology. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include vasculitis syndromes, medical physiology and rheumatic diseases, crystal deposition diseases and rheumatoid arthritis. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
