Re-imagining T-cell receptor signaling: parallel paths may be key to discriminatory power.

Abstract

T-cells are important arms of our immune system and are central to our fight against pathogens and cancers (Baral et al. 2019a; Waldman et al. 2020). They recognize infected and cancerous cells and help destroy them while leaving uninfected/normal cells intact. They accomplish this tricky task with exquisite precision. How they do so has been an enigma and the subject of intense investigation for decades (Chakraborty and Weiss 2014; Courtney et al. 2018).