Elena Marin-Diez, Jaime Viera-Artiles, David Mato-Mañas, Enrique Marco de Lucas
{"title":"Brain necrosis induced by intranasal cocaine in a patient with a history of craniofacial resection: A case report.","authors":"Elena Marin-Diez, Jaime Viera-Artiles, David Mato-Mañas, Enrique Marco de Lucas","doi":"10.1016/j.neucie.2026.500774","DOIUrl":null,"url":null,"abstract":"<p><p>A 57-year-old male woodworker was diagnosed with T3N0M0 intestinal-type nasal adenocarcinoma in 2021. He underwent endoscopic craniofacial resection and radiotherapy, with no recurrence for three years. In 2024, he presented with occipital headache and vomiting, revealing a frontal necrotic-hemorrhagic lesion with acute hydrocephalus, initially suspected to be a brain abscess. However, a history of cocaine use suggested brain necrosis facilitated by prior surgery. This unique case demonstrates brain necrosis directly attributable to intranasal cocaine use. Surgeons should consider substance use as a contributing factor in postoperative complications after skull base surgery.</p>","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":" ","pages":"500774"},"PeriodicalIF":0.0000,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurocirugia (English Edition)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.neucie.2026.500774","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A 57-year-old male woodworker was diagnosed with T3N0M0 intestinal-type nasal adenocarcinoma in 2021. He underwent endoscopic craniofacial resection and radiotherapy, with no recurrence for three years. In 2024, he presented with occipital headache and vomiting, revealing a frontal necrotic-hemorrhagic lesion with acute hydrocephalus, initially suspected to be a brain abscess. However, a history of cocaine use suggested brain necrosis facilitated by prior surgery. This unique case demonstrates brain necrosis directly attributable to intranasal cocaine use. Surgeons should consider substance use as a contributing factor in postoperative complications after skull base surgery.