Limited-Stage Small-Cell Lung Cancer With Severe Paraneoplastic Limbic Encephalitis Successfully Treated With Chemoradiotherapy Followed by Immune Checkpoint Inhibitor Maintenance Therapy: A Case Report

IF 3.9 3区医学 Q2 ONCOLOGY

Clinical lung cancer Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI:10.1016/j.cllc.2026.01.011

Daisuke Morinaga , Hidenori Kitai , Hanko Sato , Doppo Fukui , Wataru Harabayashi , Yukiko Yoshida , Shotaro Ito , Yuta Takashima , Megumi Furuta , Akihiko Kudo , Shintaro Fujii , Hisashi Uwatoko , Hiroaki Yaguchi , Keiko Tanaka , Ichiro Yabe , Jun Sakakibara-Konishi , Satoshi Konno

引用次数: 0

Abstract

•
Tissue-based assays can reveal neuronal antibody reactivity and support the diagnosis of autoimmune or paraneoplastic encephalitis, especially when standard serum and cerebrospinal fluid antibody panels are negative.
•
In limited-stage small-cell lung cancer with paraneoplastic limbic encephalitis, immune checkpoint inhibitors can be a feasible option when both tumor regression and neurological stabilization are achieved following concurrent chemoradiotherapy.

查看原文本刊更多论文

放化疗后免疫检查点抑制剂维持治疗成功治疗有限期小细胞肺癌伴严重副肿瘤边缘脑炎1例报告。

•基于组织的检测可以揭示神经元抗体反应性，支持自身免疫或副肿瘤脑炎的诊断，特别是当标准血清和脑脊液抗体检测结果为阴性时。•在伴有副肿瘤边缘脑炎的有限期小细胞肺癌中，当同步放化疗后肿瘤消退和神经系统稳定时，免疫检查点抑制剂可能是一种可行的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical lung cancer 医学-肿瘤学

CiteScore

7.00

自引率

2.80%

发文量

159

审稿时长

24 days

期刊介绍： Clinical Lung Cancer is a peer-reviewed bimonthly journal that publishes original articles describing various aspects of clinical and translational research of lung cancer. Clinical Lung Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of lung cancer. The main emphasis is on recent scientific developments in all areas related to lung cancer. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.