Lifetime ovulations and endometrial cancer risk: A systematic review and meta-analysis

IF 4.5 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Gynecologic oncology Pub Date : 2026-03-01 Epub Date: 2026-02-20 DOI:10.1016/j.ygyno.2026.02.006

Niki Talebian , Mahdi Falah Tafti , Sogol Alikarami , Francesmary Modugno

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引用次数: 0

Abstract

Background

Lifetime ovulatory years (LOY) estimate the period women are exposed to gonadal hormones in their reproductive life. Research on the relationship between endometrial cancer (EC) and lifetime ovulations is limited. This study investigates the association between LOY and EC risk.

Methods

Scopus, PubMed/MEDLINE, and Embase were systematically searched through February 8, 2026, to identify studies reporting the association between lifetime ovulations and EC risk. Two independent reviewers screened the records for eligibility, performed quality assessment, and extracted the relevant data, with disagreements resolved by a third senior reviewer. The pooled effect estimate with a 95% confidence interval was calculated using the random-effects and the meta-regression models.

Results

Eleven articles were included in the meta-analysis, of which 6 reported odds ratios, 3 reported hazard ratios, 1 reported incidence rate ratios, and 1 reported risk ratios. Two studies reporting LOY as a continuous variable were included only in the qualitative review. Higher LOY was associated with increased risk of EC with a pooled effect estimate of 2.73 (95% CI: 2.00–3.71). Women with the highest LOY had 2.07 times the odds of EC than women with the lowest LOY (95% CI: 1.50–2.85). Moreover, the pooled hazard ratio was 5.27 (95% CI: 3.43–8.10). Leave-one-out analysis did not significantly change the pooled estimates.

Conclusions

LOY is a risk factor for EC. Further studies with a standard definition of LOY are necessary to assess its association with EC risk more precisely.

PROSPERO Registration: 13 September 2025, CRD420251146449.

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查看原文本刊更多论文

终生排卵与子宫内膜癌风险：系统回顾和荟萃分析。

背景：终身排卵年（LOY）估计女性在其生殖生命中暴露于性腺激素的时期。子宫内膜癌（EC）与终生排卵之间的关系研究有限。本研究探讨LOY和EC风险之间的关系。方法：系统检索截至2026年2月8日的Scopus、PubMed/MEDLINE和Embase，以确定报告终生排卵与EC风险之间关联的研究。两名独立的审稿人筛选记录的合格性，进行质量评估，并提取相关数据，分歧由第三名高级审稿人解决。使用随机效应和元回归模型计算具有95%置信区间的合并效应估计。结果：11篇文章被纳入meta分析，其中6篇报道了优势比，3篇报道了危险比，1篇报道了发病率比，1篇报道了风险比。两项报告LOY为连续变量的研究仅纳入定性评价。较高的LOY与EC风险增加相关，合并效应估计为2.73 （95% CI: 2.00-3.71）。LOY最高的女性患EC的几率是LOY最低的女性的2.07倍（95% CI: 1.50-2.85）。合并风险比为5.27 （95% CI: 3.43-8.10）。留一分析没有显著改变汇总估计。结论：LOY是EC的危险因素。有必要进一步研究LOY的标准定义，以更准确地评估其与EC风险的关系。普洛斯彼罗注册：2025年9月13日，CRD420251146449。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gynecologic oncology 医学-妇产科学

CiteScore

8.60

自引率

6.40%

发文量

1062

审稿时长

37 days

期刊介绍： Gynecologic Oncology, an international journal, is devoted to the publication of clinical and investigative articles that concern tumors of the female reproductive tract. Investigations relating to the etiology, diagnosis, and treatment of female cancers, as well as research from any of the disciplines related to this field of interest, are published. Research Areas Include: • Cell and molecular biology • Chemotherapy • Cytology • Endocrinology • Epidemiology • Genetics • Gynecologic surgery • Immunology • Pathology • Radiotherapy