Effect of age on restrictive and liberal transfusion outcomes in patients with anemia and myocardial infarction

IF 3.5 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

American heart journal Pub Date : 2026-07-01 Epub Date: 2026-02-19 DOI:10.1016/j.ahj.2026.107381

Andrew M. Goldsweig MD, MS , Colleen M. Ballantyne MPH , Harvey D. White MD , Jinnette Dawn Abbott MD , Dean A. Fergusson PhD , Brandon M. Herbert MPH, PhD , Shaun G. Goodman MD, MSc , Jeffrey L. Carson MD , Maria M. Brooks PhD , MINT Investigators

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引用次数: 0

Abstract

For patients with anemia and myocardial infarction (MI), the randomized, 3,504-patient MINT trial found that a liberal transfusion threshold (10 g/dL) may be preferable to a restrictive threshold (8 g/dL) in terms of death or MI. The relative effects of liberal versus restrictive transfusion in younger and older patients are unknown. The present prespecified MINT substudy found no significant interaction between age and transfusion strategy for death or MI, heart failure, revascularization procedures, cardiac death, pulmonary embolism or deep vein thrombosis, bacteremia or pneumonia, and death at 30 and 180 days. A liberal transfusion approach appears to be safe and may be the preferred transfusion strategy in anemic patients with MI, regardless of age.

MINT Trial, ClinicalTrials.gov Number NCT02981407, https://www.minttrial.org/.

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年龄对贫血和心肌梗死患者限制性和自由输血结局的影响。

对于贫血和心肌梗死患者，随机3504例患者的MINT试验发现，在死亡或心肌梗死方面，自由输血阈值（10g /dL）可能优于限制性阈值（8g /dL）。自由输血与限制输血对年轻和老年患者的相对影响尚不清楚。目前预先指定的MINT亚研究发现，年龄与输血策略在死亡或心肌梗死、心力衰竭、血管重建手术、心源性死亡、肺栓塞或深静脉血栓形成、菌血症或肺炎和30天和180天死亡之间没有显著的相互作用。自由输血方法似乎是安全的，可能是心肌梗死贫血患者的首选输血策略，无论年龄如何。MINT试验，ClinicalTrials.gov编号NCT02981407， https://www.minttrial.org/。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American heart journal 医学-心血管系统

CiteScore

8.20

自引率

2.10%

发文量

214

审稿时长

38 days

期刊介绍： The American Heart Journal will consider for publication suitable articles on topics pertaining to the broad discipline of cardiovascular disease. Our goal is to provide the reader primary investigation, scholarly review, and opinion concerning the practice of cardiovascular medicine. We especially encourage submission of 3 types of reports that are not frequently seen in cardiovascular journals: negative clinical studies, reports on study designs, and studies involving the organization of medical care. The Journal does not accept individual case reports or original articles involving bench laboratory or animal research.