The effect of ciclopiroxolamine investigated by means of the freeze-fracture technique.

Abstract

Summary: The authors report on the membrane alterations induced in vitro in dermatophytes and yeasts by the action of ciclopiroxolamine. The investigation was performed by means of the freeze‐fracture technique and revealed modifications in particle distribution on the plasma membrane of both dermatophytes and Candida albicans; moreover, in the latter, the characteristic furrows observed on the P face showed a peculiar re‐arrangement.