Comparison of the in vitro cytotoxicities and acute in vivo toxicities of 59 chemicals.

Molecular toxicology Pub Date : 1987-09-01
R H Clothier, L M Hulme, M Smith, M Balls
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Abstract

The in vitro cytotoxicities of 59 chemicals, expressed as ID50 values (i.e., concentrations of test chemicals that reduced the final cellular protein content of test cultures by 50% in comparison with appropriate solvent control cultures) and obtained using murine 3T3-L1 cells and the FRAME kenacid blue method, have been compared with rat oral and mouse intraperitoneal (ip) LD50 values. A better in vivo/in vitro correlation was obtained for the 59 chemicals with mouse ip LD50 values (r = .80) than with rat oral LD50 values (r = .76), but the best in vivo/in vitro correlation was found when the most toxic of the rat and mouse values were used in the comparison (r = .81).

59种化学物质体外细胞毒性与体内急性毒性的比较。
用小鼠3T3-L1细胞和FRAME ken酸蓝法获得的59种化学物质的体外细胞毒性,用ID50值表示(即,与适当的溶剂对照培养物相比,试验化学物质的浓度使试验培养物的最终细胞蛋白含量降低50%),并与大鼠口服和小鼠腹腔内(ip) LD50值进行了比较。59种化学物质与小鼠体内LD50值(r = 0.80)的体内外相关性优于与大鼠口服LD50值(r = 0.76),但以大鼠和小鼠毒性最大值进行比较时,体内外相关性最好(r = 0.81)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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